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Asterriquinol D dimethyl ether Sale

目录号 : GC41640

A fungal metabolite

Asterriquinol D dimethyl ether Chemical Structure

Cas No.:287117-66-2

规格 价格 库存 购买数量
1mg
¥2,141.00
现货
5mg
¥9,645.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Asterriquinol D dimethyl ether is a fungal metabolite that has been found in A. kumbius. It is cytotoxic to NS-1 mouse myeloma cells (IC50 = 28 μg/ml) and has activity against T. foetus in vitro (IC50 = 100 μg/ml).

Chemical Properties

Cas No. 287117-66-2 SDF
Canonical SMILES COC1=C(C2=CNC3=C2C=CC=C3)C(OC)=C(OC)C(C4=CNC5=C4C=CC=C5)=C1OC
分子式 C26H24N2O4 分子量 428.5
溶解度 Soluble in DMSO 储存条件 Store at -20°C
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.3337 mL 11.6686 mL 23.3372 mL
5 mM 0.4667 mL 2.3337 mL 4.6674 mL
10 mM 0.2334 mL 1.1669 mL 2.3337 mL
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Research Update

Bis-Indolyl Benzenoids, Hydroxypyrrolidine Derivatives and Other Constituents from Cultures of the Marine Sponge-Associated Fungus Aspergillus candidus KUFA0062

Mar Drugs 2018 Apr 6;16(4):119.PMID:29642369DOI:PMC5923406

A previously unreported bis-indolyl benzenoid, candidusin D (2e) and a new hydroxypyrrolidine alkaloid, preussin C (5b) were isolated together with fourteen previously described compounds: palmitic acid, clionasterol, ergosterol 5,8-endoperoxides, chrysophanic acid (1a), emodin (1b), six bis-indolyl benzenoids including Asterriquinol D dimethyl ether (2a), petromurin C (2b), kumbicin B (2c), kumbicin A (2d), 2″-oxoasterriquinol D methyl ether (3), kumbicin D (4), the hydroxypyrrolidine alkaloid preussin (5a), (3S, 6S)-3,6-dibenzylpiperazine-2,5-dione (6) and 4-(acetylamino) benzoic acid (7), from the cultures of the marine sponge-associated fungus Aspergillus candidus KUFA 0062. Compounds 1a, 2a-e, 3, 4, 5a-b, and 6 were tested for their antibacterial activity against Gram-positive and Gram-negative reference and multidrug-resistant strains isolated from the environment. Only 5a exhibited an inhibitory effect against S. aureus ATCC 29213 and E. faecalis ATCC29212 as well as both methicillin-resistant S. aureus (MRSA) and vancomycin-resistant enterococci (VRE) strains. Both 1a and 5a also reduced significant biofilm formation in E. coli ATCC 25922. Moreover, 2b and 5a revealed a synergistic effect with oxacillin against MRSA S. aureus 66/1 while 5a exhibited a strong synergistic effect with the antibiotic colistin against E. coli 1410/1. Compound 1a, 2a-e, 3, 4, 5a-b, and 6 were also tested, together with the crude extract, for cytotoxic effect against eight cancer cell lines: HepG2, HT29, HCT116, A549, A 375, MCF-7, U-251, and T98G. Except for 1a, 2a, 2d, 4, and 6, all the compounds showed cytotoxicity against all the cancer cell lines tested.