Atomoxetine HCl
(Synonyms: 盐酸托莫西汀; Tomoxetine hydrochloride; (R)-Tomoxetine hydrochloride; LY 139603) 目录号 : GC10274
A selective norepinephrine reuptake inhibitor
Cas No.:82248-59-7
Sample solution is provided at 25 µL, 10mM.
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Atomoxetine HCl is a selective norepinephrine transporter inhibitor (Ki= 5 nM)
Norepinephrine transporter is a multi-pass membrane protein that is essential for norepinephrine reuptake into presynaptic nerve terminals and regulates norepinephrine homeostasis.
Atomoxetine blocked coupling of radioligands to clonal cell lines that transfected with human norepinephrine transporter, serotonin and dopamine transporters with Ki= 5, 77 and 1451 nM respectively. [1]
In microdialysis studies in rat, atomoxetine increases extracellular levels of norepinephrine transporter in prefrontal cortex 3-fold without altering 5-HTEX levels. Atomoxetine also increases DAEX concentrations in PFC 3-fold without altering DAEX in striatum or nucleus accumbens. Comparing with methylphenidate, atomoxetine do not increase DA in striatum or nucleus accumbens, indicating it would not have motoric or drug abuse liabilities. [1]
Reference:
Bymaster FP, Katner JS, Nelson DL et al. Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology. 2002 Nov;27(5):699-711.
| Cas No. | 82248-59-7 | SDF | |
| 别名 | 盐酸托莫西汀; Tomoxetine hydrochloride; (R)-Tomoxetine hydrochloride; LY 139603 | ||
| 化学名 | (3R)-N-methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine;hydrochloride | ||
| Canonical SMILES | CC1=CC=CC=C1OC(CCNC)C2=CC=CC=C2.Cl | ||
| 分子式 | C17H22ClNO | 分子量 | 291.82 |
| 溶解度 | ≥ 14.35mg/mL in DMSO | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.4268 mL | 17.1338 mL | 34.2677 mL |
| 5 mM | 0.6854 mL | 3.4268 mL | 6.8535 mL |
| 10 mM | 0.3427 mL | 1.7134 mL | 3.4268 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet