Bavachalcone (Broussochalcone B)
(Synonyms: 补骨脂查耳酮; 补骨酯查儿酮; Broussochalcone B) 目录号 : GC33139
A chalcone and flavonoid with diverse biological activities
Cas No.:28448-85-3
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Bavachalcone is a polyketide synthase-derived chalcone and flavonoid that has been found in P. corylifolia and has diverse biological activities.1,2,3,4,5 It inhibits α-glucosidase and the UDP-glucuronosyltransferase (UGT) isoforms UGT1A1 and UGT1A7 (IC50s = 11.1, 11.3, and 3.6 ?M, respectively).2,3 Bavachalcone is cytotoxic to K562 chronic myeloid leukemia cells (IC50 = 2.77 ?M).4 It inhibits RANKL-induced osteoclastogenesis of isolated mouse bone marrow-derived macrophages (BMDMs) when used at a concentration of 5 ?g/ml.5
1.Zhou, K., Yang, S., and Li, S.-M.Naturally occurring prenylated chalcones from plants: Structural diversity, distribution, activities and biosynthesisNat. Prod. Rep.(2021) 2.Ryu, H.W., Lee, B.W., Curtis-Long, M.J., et al.Polyphenols from Broussonetia papyrifera displaying potent α-glucosidase inhibitionJ. Agric. Food Chem.58(1)202-208(2010) 3.Shan, L., Yang, S., Zhang, G., et al.Comparison of the inhibitory potential of bavachalcone and corylin against UDP-glucuronosyltransferasesEvid. Based Complement. Alternat. Med.958937(2014) 4.Wang, H.-M., Zhang, L., Liu, J., et al.Synthesis and anti-cancer activity evaluation of novel prenylated and geranylated chalcone natural products and their analogsEur. J. Med. Chem.92439-448(2015) 5.Park, C.K., Lee, Y., Chang, E.-J., et al.Bavachalcone inhibits osteoclast differentiation through suppression of NFATc1 induction by RANKLBiochem. Pharmacol.75(11)2175-2182(2008)
| Cas No. | 28448-85-3 | SDF | |
| 别名 | 补骨脂查耳酮; 补骨酯查儿酮; Broussochalcone B | ||
| Canonical SMILES | O=C(C1=CC(C/C=C(C)\C)=C(O)C=C1O)/C=C/C2=CC=C(O)C=C2 | ||
| 分子式 | C20H20O4 | 分子量 | 324.37 |
| 溶解度 | DMSO : ≥ 34 mg/mL (104.82 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 3.0829 mL | 15.4145 mL | 30.829 mL |
| 5 mM | 0.6166 mL | 3.0829 mL | 6.1658 mL |
| 10 mM | 0.3083 mL | 1.5414 mL | 3.0829 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Assessment of Psoralea fructus by HPLC Fingerprint Coupled with Multi-components Analysis
Indian J Pharm Sci 2015 Nov-Dec;77(6):715-22.PMID:26997699DOI:PMC4778231
Psoralea Fructus, the dried and ripe fruit of Psoralea corylifolia L., have been used as traditional medicine. There is substantial evidence that multiple constituents are responsible for the beneficial effects of this medicine. To effectively control the quality of this herbal medicine, HPLC fingerprint analysis was performed on a SinoChrom ODS-BP column with mobile phase of a gradient prepared from H2O and CH3CN, which the conditions used for gradient elution were: 0-10 min, 5-45% CH3CN; 10-45 min, 45-70% CH3CN; 45-50 min, 70-100% CH3CN; 50-60 min, 100-100% CH3CN, and the flow rate was 1.0 ml/min. It was obtained on the basis of the chromatographic data from 28 batches of samples, which contained 26 common peaks and 13 peaks were identified by the electrospray ionization-mass spectrometry as psoralen, isopsoralen, isobavachin, neobavaisoflavone, bavachin, corylin, Broussochalcone B, psoralidin, isobavachalcone, bavachinin, corylifol A, Bavachalcone and backuchiol. The contents of these 13 compounds were also simultaneously examined. By using principal component analysis, 28 batches of samples collected from 6 producing locations with different collecting time were evaluated and differentiated. In summary, the data as described in this study offer valuable information for quality control and proper use of Psoralea Fructus.