Bavachalcone (Broussochalcone B)
(Synonyms: 补骨脂查耳酮; 补骨酯查儿酮; Broussochalcone B) 目录号 : GC33139
A chalcone and flavonoid with diverse biological activities
Cas No.:28448-85-3
Sample solution is provided at 25 µL, 10mM.
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Bavachalcone is a polyketide synthase-derived chalcone and flavonoid that has been found in P. corylifolia and has diverse biological activities.1,2,3,4,5 It inhibits α-glucosidase and the UDP-glucuronosyltransferase (UGT) isoforms UGT1A1 and UGT1A7 (IC50s = 11.1, 11.3, and 3.6 ?M, respectively).2,3 Bavachalcone is cytotoxic to K562 chronic myeloid leukemia cells (IC50 = 2.77 ?M).4 It inhibits RANKL-induced osteoclastogenesis of isolated mouse bone marrow-derived macrophages (BMDMs) when used at a concentration of 5 ?g/ml.5
1.Zhou, K., Yang, S., and Li, S.-M.Naturally occurring prenylated chalcones from plants: Structural diversity, distribution, activities and biosynthesisNat. Prod. Rep.(2021) 2.Ryu, H.W., Lee, B.W., Curtis-Long, M.J., et al.Polyphenols from Broussonetia papyrifera displaying potent α-glucosidase inhibitionJ. Agric. Food Chem.58(1)202-208(2010) 3.Shan, L., Yang, S., Zhang, G., et al.Comparison of the inhibitory potential of bavachalcone and corylin against UDP-glucuronosyltransferasesEvid. Based Complement. Alternat. Med.958937(2014) 4.Wang, H.-M., Zhang, L., Liu, J., et al.Synthesis and anti-cancer activity evaluation of novel prenylated and geranylated chalcone natural products and their analogsEur. J. Med. Chem.92439-448(2015) 5.Park, C.K., Lee, Y., Chang, E.-J., et al.Bavachalcone inhibits osteoclast differentiation through suppression of NFATc1 induction by RANKLBiochem. Pharmacol.75(11)2175-2182(2008)
| Cas No. | 28448-85-3 | SDF | |
| 别名 | 补骨脂查耳酮; 补骨酯查儿酮; Broussochalcone B | ||
| Canonical SMILES | O=C(C1=CC(C/C=C(C)\C)=C(O)C=C1O)/C=C/C2=CC=C(O)C=C2 | ||
| 分子式 | C20H20O4 | 分子量 | 324.37 |
| 溶解度 | DMSO : ≥ 34 mg/mL (104.82 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 3.0829 mL | 15.4145 mL | 30.829 mL |
| 5 mM | 0.6166 mL | 3.0829 mL | 6.1658 mL |
| 10 mM | 0.3083 mL | 1.5414 mL | 3.0829 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet