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BAY-1895344 Sale

(Synonyms: BAY 1895344) 目录号 : GC33420

An ATR inhibitor

BAY-1895344 Chemical Structure

Cas No.:1876467-74-1

规格 价格 库存 购买数量
5mg
¥990.00
现货
10mg
¥1,584.00
现货
25mg
¥2,880.00
现货
50mg
¥4,680.00
现货
100mg
¥7,830.00
现货
500mg
¥9,238.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

BAY-1895344 is an inhibitor of ataxia-telangiectasia and Rad3-related protein/kinase (ATR; IC50 = 0.007 ?M).1,2 It is selective for ATR over DNA protein kinase (DNA-PK), ataxia-telangiectasia mutated kinase (ATM), and PI3Kβ (IC50s = 0.332, 1.42, and 3.27 ?M, respectively).1 BAY-1895344 inhibits proliferation of HT-29 and LoVo colorectal cancer cells and SU-DHL-8 B lymphoma cells with IC50 values of 0.16, 0.071, and 0.009 ?M, respectively. It reduces tumor growth in a mutant ATMK1964E-containing SU-DHL-8 mouse xenograft model when administered at a dose of 50 mg/kg. BAY-1895344 is synergistic with carboplatin , olaparib , or radiation in various mouse xenograft models.1,2

1.Lücking, U., Wortmann, L., Wengner , A.M., et al.Damage incorporated: Discovery of the potent, highly selective, orally available ATR inhibitor BAY 1895344 with favorable pharmacokinetic properties and promising efficacy in monotherapy and in combination treatments in preclinical tumor modelsJ. Med. Chem.63(13)7293-7325(2020) 2.Wengner, A.M., Siemeister, G., Lücking, U., et al.The novel ATR inhibitor BAY 1895344 Is efficacious as monotherapy and combined with DNA damage-inducing or repair-compromising therapies in preclinical cancer modelsMol. Cancer Ther.19(1)26-38(2020)

Chemical Properties

Cas No. 1876467-74-1 SDF
别名 BAY 1895344
Canonical SMILES CN1N=CC=C1C2=CC(N3[C@H](C)COCC3)=NC4=C(C5=NNC=C5)N=CC=C24
分子式 C20H21N7O 分子量 375.43
溶解度 DMSO: 5.4 mg/mL (14.38 mM) 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.6636 mL 13.3181 mL 26.6361 mL
5 mM 0.5327 mL 2.6636 mL 5.3272 mL
10 mM 0.2664 mL 1.3318 mL 2.6636 mL
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