Bendiocarb
(Synonyms: 恶虫威) 目录号 : GC46915
A broad-spectrum carbamate insecticide
Cas No.:22781-23-3
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Bendiocarb is a broad-spectrum carbamate insecticide and an inhibitor of acetylcholinesterase (Ki = 111 nM for the human enzyme).1 It is active against several species, including second stage nymph German cockroaches (B. germanica; IC50 = <0.5 mg/ft2) and adult yellow fever mosquitoes (A. aegypti; IC50 = <0.03 mg/ft2).2 It is toxic to mammalian species with an oral LD50 value of 45 mg/kg for male rats and female mice, but it is metabolized and excreted rapidly and has a dermal LD50 of 800 mg/kg after a 24-hour exposure. Formulations containing bendiocarb have been used in the indoor control of insects, including for mosquitoes in areas with malaria transmission.
1.Verma, A., Wong, D.M., Islam, R., et al.3-Oxoisoxazole-2(3H)-carboxamides and isoxazol-3-yl carbamates: Resistance-breaking acetylcholinesterase inhibitors targeting the malaria mosquito, Anopheles gambiaeBioorg. Med. Chem.23(6)1321-1340(2015) 2.Brooker, P.J., Gates, P.S., Gillon, J., et al.Insecticidal activity of certain benzodioxolyl carbamatesPestic. Sci.3(6)735-744(1972)
| Cas No. | 22781-23-3 | SDF | |
| 别名 | 恶虫威 | ||
| Canonical SMILES | CC1(C)OC2=C(OC(NC)=O)C=CC=C2O1 | ||
| 分子式 | C11H13NO4 | 分子量 | 223.2 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:9): 0.1 mg/ml,Ethanol: 5 mg/ml | 储存条件 | Store at Room temperature |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.4803 mL | 22.4014 mL | 44.8029 mL |
| 5 mM | 0.8961 mL | 4.4803 mL | 8.9606 mL |
| 10 mM | 0.448 mL | 2.2401 mL | 4.4803 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Bendiocarb-induced nephrotoxicity in rats and the protective role of vitamins C and E
Environ Sci Pollut Res Int 2020 Feb;27(6):6449-6458.PMID:31873894DOI:10.1007/s11356-019-07260-x.
Bendiocarb is a pesticide carbamate which is used to protect agricultural products and animals. In this study, rats were given orally with Bendiocarb and also other chemicals via gavage. Male rats were randomly divided into eight groups (n = 6): group 1 served as controls; group 2 received vitamin C (100 mg/kg bw); group 3 received vitamin E (100 mg/kg bw); group 4 received vitamins C plus E; group 5 received Bendiocarb (0.8 mg/kg 1/50 LD50); group 6 received both Bendiocarb and vitamin C; group 7 received both Bendiocarb and vitamin E; and group 8 received both Bendiocarb and vitamin C and E via oral gavage. Degenerative changes and biochemical differences in rat kidney were investigated after 4 weeks of especially Bendiocarb treatment. While biochemical values were normal in the control group, it was observed that CAT, SOD, GPx, and GST values decreased, while MDA, creatine, urea, and uric acid values increased in the pesticide-treated groups. It was also reported that Bendiocarb caused cytopathological and histopathological changes in rat kidney. We have shown that the application of vitamins has a therapeutic effect on the evaluated parameters.
Bendiocarb and Malathion Resistance in Two Major Malaria Vector Populations in Cameroon Is Associated with High Frequency of the G119S Mutation (Ace-1) and Overexpression of Detoxification Genes
Pathogens 2022 Jul 23;11(8):824.PMID:35894047DOI:10.3390/pathogens11080824.
The spread of pyrethroid resistance in malaria vectors is a major threat affecting the performance of current control measures. However, there is still not enough information on the resistance profile of mosquitoes to carbamates and organophosphates which could be used as alternatives. The present study assessed the resistance profile of Anopheles gambiae s.l. to Bendiocarb and malathion, at the phenotypic and molecular levels, in different eco-epidemiological settings in Cameroon. Anopheles gambiae s.l. mosquitoes were collected from four eco-epidemiological settings across the country and their susceptibility level to Bendiocarb and malathion was determined using WHO tubes bioassays. The ace-1 target site G119S mutation was screened by PCR. Reverse Transcription quantitative PCR 3-plex TaqMan assays were used to quantify the level of expression of eight genes associated with metabolic resistance. Resistance to malathion and/or Bendiocarb was recorded in all study sites except in mosquitoes collected in Kaélé and Njombé. The Ace-1 (G119S) mutation was detected in high frequencies (>40%) in Kékem and Santchou. Both An. gambiae and An. coluzzii were detected carrying this mutation. The cytochrome P450s gene Cyp6p3 associated with carbamate resistance and the glutathione S-transferase gene Gste2 associated with organophosphate resistance were found to be overexpressed. Genes associated with pyrethroid (Cyp6m2, Cyp9k1, Cyp6p3) and organochlorine (Gste2, Cyp6z1, Cyp6m2) and cuticle resistance (Cyp4g16) were also overexpressed. The rapid spread of resistance to organophosphates and carbamates could seriously compromise future control strategies based on IRS. It is therefore becoming important to assess the magnitude of Bendiocarb and malathion resistance countrywide.
Bioefficacy of Bendiocarb WP80 in vector-borne and zoonotic diseases areas in borderline of Iran and Pakistan
Toxicol Res (Camb) 2021 Jul 27;10(4):868-874.PMID:34484678DOI:10.1093/toxres/tfab070.
Malaria and leishmaniasis are the public health problems in southern Iran. The main activity of vector control is indoor residual spraying using pyrethroids, using different insecticides as larviciding and impregnated bednets. The aim of study was to evaluate the biological assays of Bendiocarb wettable powder (WP) at different surfaces of wall. The residual effect of Bendiocarb WP80 at 400 milligram/meter square (mg/m2) was evaluated on various local surfaces of rooms such as mud and plaster as well as thatch roofs and wooden. World Health Organization standard cones using contact bioassays were carried out using laboratory reared sugar-fed, 48-72 h old females of Anopheles stephensi. Contact bioassays were carried out on sprayed surfaces for 150 days. Contact bioassay on surfaces treated with Bendiocarb WP80 at different surfaces was estimated about 2 months. Fumigant tests of Bendiocarb WP80 at 400 mg/m2 revealed 50-93.83% mortality with 1 month persistency. The results showed that carbamate insecticide could be used as rotation with pyrethroids for malaria vector control. Monitoring and evaluation of environmental toxicology of pesticides is important for decision making for choosing appropriate pesticides for disease vector control.
First evaluation of Bendiocarb in experimental huts using different substrates in Madagascar
Malar J 2016 May 26;15(1):293.PMID:27230626DOI:10.1186/s12936-016-1345-z.
Background: Indoor residual spraying with insecticide is recommended for malaria control in high-transmission settings. Determination of residual activity of insecticides is essential for the selection of appropriate indoor spraying policy. The present study was undertaken to evaluate the residual effect of Bendiocarb, a carbamate insecticide used in Madagascar, on different indoor surfaces in order to elaborate future vector control interventions. Methods: The residual activity of Bendiocarb was evaluated in both experimental huts and houses. Tests in experimental huts on different substrates represented a small scale-field trials. The houses IRS performed in parallel of experimental huts IRS, was done to compare semi-field results and field results. Bioassays according to the World Health Organization (WHO) standard protocol were carried out on different substrates impregnated with Bendiocarb using susceptible strains of Anopheles arabiensis and Aedes albopictus. Results: Bendiocarb induced significantly high mortality in treated huts against exposed mosquito (p < 0.005) compared to untreated huts. The mortality is up to the WHO threshold of 80 % during 5 months post-treatment. Using a multivariate analysis, Ae. albopictus mortality decreased significantly from the 3rd month post-treatment. However, An. arabiensis mortality decreased significantly from the 4th month after treatment. Comparing mosquito mortality results from the mud experimental huts and the mud houses showed no significant difference regarding the persistence of Bendiocarb on wall. Conclusions: Current data suggest variable persistence of Bendiocarb according to the type of wall surfaces, highlighting the importance of testing insecticide for IRS in local context before using them in large scale. Data from this study validate also the importance of using experimental huts as representative tool to evaluate the effectiveness of an insecticide.
Bendiocarb induced histopathological and biochemical alterations in rat liver and preventive role of vitamins C and E
Environ Toxicol Pharmacol 2017 Jan;49:148-155.PMID:28013143DOI:10.1016/j.etap.2016.11.018.
In this study, biochemical changes and histological structure of rat liver after Bendiocarb administration and possible preventive effects of vitamins C and E were studied. The animals were given with Bendiocarb, vitamin C and vitamin E, daily 0,8mg/kg of body weight (bw), 100mg/kg-bw and 100mg/kg-bw for 28days, respectively. Lipid peroxidation, antioxidant enzyme activities, histological alterations and antioxidant capacity assays of liver and also liver function tests and lipid profile were measured. Bendiocarb treatment decreased the antioxidant enzyme activities, FRAP and TEAC values and increased malondialdehyde levels compared to control. Also, there were statistically significant alterations in liver function tests, lipid profile parameters and histopathological changes in Bendiocarb treated groups. Vitamins C and E showed protective effects against examining parameters. According to results we can say that co-treatment of vitamin C and vitamin E may be more effective than use of them alone.