Bendiocarb
(Synonyms: 恶虫威) 目录号 : GC46915
A broad-spectrum carbamate insecticide
Cas No.:22781-23-3
Sample solution is provided at 25 µL, 10mM.
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Bendiocarb is a broad-spectrum carbamate insecticide and an inhibitor of acetylcholinesterase (Ki = 111 nM for the human enzyme).1 It is active against several species, including second stage nymph German cockroaches (B. germanica; IC50 = <0.5 mg/ft2) and adult yellow fever mosquitoes (A. aegypti; IC50 = <0.03 mg/ft2).2 It is toxic to mammalian species with an oral LD50 value of 45 mg/kg for male rats and female mice, but it is metabolized and excreted rapidly and has a dermal LD50 of 800 mg/kg after a 24-hour exposure. Formulations containing bendiocarb have been used in the indoor control of insects, including for mosquitoes in areas with malaria transmission.
1.Verma, A., Wong, D.M., Islam, R., et al.3-Oxoisoxazole-2(3H)-carboxamides and isoxazol-3-yl carbamates: Resistance-breaking acetylcholinesterase inhibitors targeting the malaria mosquito, Anopheles gambiaeBioorg. Med. Chem.23(6)1321-1340(2015) 2.Brooker, P.J., Gates, P.S., Gillon, J., et al.Insecticidal activity of certain benzodioxolyl carbamatesPestic. Sci.3(6)735-744(1972)
| Cas No. | 22781-23-3 | SDF | |
| 别名 | 恶虫威 | ||
| Canonical SMILES | CC1(C)OC2=C(OC(NC)=O)C=CC=C2O1 | ||
| 分子式 | C11H13NO4 | 分子量 | 223.2 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:9): 0.1 mg/ml,Ethanol: 5 mg/ml | 储存条件 | Store at Room temperature |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.4803 mL | 22.4014 mL | 44.8029 mL |
| 5 mM | 0.8961 mL | 4.4803 mL | 8.9606 mL |
| 10 mM | 0.448 mL | 2.2401 mL | 4.4803 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet