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Beraprost sodium Sale

(Synonyms: (Rac)-贝拉前列素钠) 目录号 : GC38891

A stable, orally active analog of prostacyclin

Beraprost sodium Chemical Structure

Cas No.:496807-11-5

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥2,970.00
现货
5mg
¥2,700.00
现货
10mg
¥4,500.00
现货
25mg
¥8,550.00
现货
50mg 待询 待询
100mg 待询 待询

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Sample solution is provided at 25 µL, 10mM.

Description

Beraprost is an analog of prostacyclin in which the unstable enol-ether has been replaced by a benzofuran ether function. This modification increases the plasma half-life from 30 seconds to several hours, and permits the compound to be taken orally. Doses of 20-100 ?g in humans, given 1 to 3 times per day, have been demonstrated to improve clinical end points in diseases responsive to prostacyclin. Oral beraprost therapy improved the survival and pulmonary hemodynamics of patients with primary pulmonary hypertension.1 Beraprost inhibits platelet aggregation in healthy subjects and in diabetic patients at similar doses.2,3

1.Nagaya, N., Uematsu, M., Okano, Y., et al.Effect of orally active prostacyclin analogue on survival of outpatients with primary pulmonary hypertensionJ. Am. Coll. Cardiol.341188-1192(1999) 2.Nony, P., Ffrench, P., Girard, P., et al.Platelet-aggregation inhibition and hemodynamic effects of beraprost sodium, a new oral prostacyclin derivative: A study in healthy male subjectsCan. J. Physiol. Pharmacol.74887-893(1996) 3.Kato, H., Takashima, T., Kishikawa, H., et al.Effect of beraprost sodium, a stable prostaglandin I2 analogue, on platelet aggregation in diabetes mellitusInt. J. Clin. Pharmacol. Res.16(4-5)99-102(1996)

化学性质

Cas No. 496807-11-5 SDF
别名 (Rac)-贝拉前列素钠
Canonical SMILES CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@@]2([H])C3=CC=CC(CCCC(O[Na])=O)=C3O[C@@]2([H])C[C@H]1O.[Relative stereochemistry]
分子式 C24H29NaO5 分子量 420.47
溶解度 DMSO: 250 mg/mL (594.57 mM) 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.3783 mL 11.8915 mL 23.7829 mL
5 mM 0.4757 mL 2.3783 mL 4.7566 mL
10 mM 0.2378 mL 1.1891 mL 2.3783 mL
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