Betamethasone-d5
(Synonyms: β-Methasone-d5, SCH 4831-d5) 目录号 : GC52329
An internal standard for the quantification of betamethasone
Cas No.:2244574-92-1
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Betamethasone-d5 is intended for use as an internal standard for the quantification of betamethasone by GC- or LC-MS. Betamethasone is a synthetic corticosteroid.1 In vivo, betamethasone (5 mg/kg) reduces bronchoalveolar lavage fluid (BALF) matrix metalloproteinase-2 (MMP-2) and MMP-9 activities, TNF-α levels, and neutrophil number in a mouse model of LPS-induced lung injury. Prenatal administration of betamethasone (0.1 mg/kg) improves neonatal lung function but decreases hippocampal and corpus callosum neuron density and induces motor function deficits in a rabbit model of late preterm birth.2 It also extends gestational length in a rat model of preterm labor induced by high mobility group protein B1 (HMGB1).3 Formulations containing betamethasone have been used in the treatment of inflammatory skin conditions and prenatally to promote fetal lung maturation.
1.Corbel, M., Lagente, V., ThÉret, N., et al.Comparative effects of betamethasone, cyclosporin and nedocromil sodium in acute pulmonary inflammation and metalloproteinase activities in bronchoalveolar lavage fluid from mice exposed to lipopolysaccharidePulm. Pharmacol. Ther.12(3)165-171(1999) 2.van der Merwe, J., van der Veeken, L., Inversetti, A., et al.Neurocognitive sequelae of antenatal corticosteroids in a late preterm rabbit modelAm. J. Obstet. Gynecol.226(6)850.e851-850.e821(2022) 3.Galaz, J., Romero, R., Arenas-Hernandez, M., et al.Betamethasone as a potential treatment for preterm birth associated with sterile intra-amniotic inflammation: A murine studyJ. Perinat. Med.49(7)897-906(2021)
| Cas No. | 2244574-92-1 | SDF | Download SDF |
| 别名 | β-Methasone-d5, SCH 4831-d5 | ||
| Canonical SMILES | O=C1C=C[C@@]2(C)C(C([2H])([2H])C[C@]3([H])[C@]2(F)[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@H](C)[C@]4(O)C(C([2H])([2H])O)=O)=C1[2H] | ||
| 分子式 | C22H24D5FO5 | 分子量 | 397.5 |
| 溶解度 | DMSO: soluble | 储存条件 | -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.5157 mL | 12.5786 mL | 25.1572 mL |
| 5 mM | 0.5031 mL | 2.5157 mL | 5.0314 mL |
| 10 mM | 0.2516 mL | 1.2579 mL | 2.5157 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。