BGC 20-761
目录号 : GC15092
BGC 20-761 是一种选择性 5-HT6 和多巴胺受体拮抗剂（人受体 Ki 值：5-HT6 (20 nM)、5-HT2A (69 nM)、D2 (140 nM)）。
Cas No.:17375-63-2
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
BGC20-761 is a selective and high affinity antagonist of 5-HTC.
The 5-HT6 receptor, a G protein-coupled receptor (GPCR), is a subtype of 5-HT receptor which binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). This protein is expressed almost exclusively in the brain and mediates excitatory neurotransmission.
In cellular level, BGC20-761 (5-methoxy-2-phenyl-N,N-dimethyltryptamine) was shown to selectively blocked 5-HTC.
BGC20-761 was used to study the difference in drug- induced effects in memory consolidation in young and mature rats and human. In young mice, BGC20-761 treatment at doses of 5 mg/kg and 10 mg/kg i.p, dose-dependently reversed a deficit of social recognition induced by scopolamine, an anticholinergic drug that impairs memory at dosage of 0.4 mg/kg i.p. In mature rats (6 months), recognition of the novel object was improved following administration of BGC20-761. The difference in effects of BGC20-761 in young vs. mature rats may reflect the status of memory consolidation in these different age ranges 1.
Reference:
1. Mitchell ES, Hoplight BJ, Lear SP, et al. BGC20-761, a novel tryptamine analog, enhances memory consolidation and reverses scopolamine-induced memory deficit in social and visuospatial memory tasks through a 5-HT6 receptor-mediated mechanism. Neuropharmacology. 2006;50(4):412-420.
| Cas No. | 17375-63-2 | SDF | |
| 化学名 | 2-(5-methoxy-2-phenyl-1H-indol-3-yl)-N,N-dimethylethanamine | ||
| Canonical SMILES | COC1=CC2=C(NC(C3=CC=CC=C3)=C2CCN(C)C)C=C1 | ||
| 分子式 | C19H22N2O | 分子量 | 294.39 |
| 溶解度 | <14.72mg/ml in ethanol; <29.44mg/ml in DMSO | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.3969 mL | 16.9843 mL | 33.9685 mL |
| 5 mM | 0.6794 mL | 3.3969 mL | 6.7937 mL |
| 10 mM | 0.3397 mL | 1.6984 mL | 3.3969 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。