Bifenthrin

Bifenthrin is a synthetic pyrethroid insecticide that prolongs opening of sodium channels resulting in membrane depolarization and conductance block in the insect nervous system.¹ It is effective against A. gambiae and C. quinquefasciatus mosquitos (LD₅₀s = 0.15 and 0.16 ng/mg, respectively) and increases O. insidiosus mortality in treated corn and sorghum plants.^2,3 Bifenthrin exhibits aquatic toxicity, inducing reproductive defects and lethality in D. magna (LC₅₀ = 12.4 ?g/L).⁴ Acute oral administration of bifenthrin induces fine tremor, decreases motor activity and grip strength, and increases pawing and head shaking behaviors in rats, indicating typical Type I pyrethroid neurotoxicity.⁵ Bifenthrin (8 mg/kg) also decreases locomotor activity, induces anemia, elevates white blood cell counts, alanine transaminase (ALT), and superoxide dismutase (SOD), as well as decreases glutathione peroxidase (Gpx) activity in mice.⁶

1.Choi, J.S., and Soderlund, D.M.Structure-activity relationships for the action of 11 pyrethroid insecticides on rat Nav1.8 sodium channels expressed in Xenopus oocytesToxicol. Appl. Pharmacol.211(3)233-244(2006) 2.Al-Deeb, M.A., Wilde, G.E., and Zhu, K.Y.Effect of insecticides used in corn, sorghum, and alfalfa on the predator Orius insidiosus (Hemiptera: Anthocoridae)J. Econ. Entomol.94(6)1353-1360(2001) 3.Hougard, J.-M., Duchon, S., Zaim, M., et al.Bifenthrin: A useful pyrethroid insecticide for treatment of mosquito netsJ. Med. Entomol.39(3)526-533(2002) 4.Ye, W.H., Wen, Y.Z., Liu, W.P., et al.Effects of bifenthrin on Daphnia magna during chronic toxicity test and the recovery testJ. Environ. Sci. (China)16(5)843-846(2004) 5.Wolansky, M.J., McDaniel, K.L., Moser, V.C., et al.Influence of dosing volume on the neurotoxicity of bifenthrinNeurotoxicol. Teratol.29(3)377-384(2007) 6.Nieradko-Iwanicka, B., Borzecki, A., and Jodlowska-Jedrych, B.Effect of subacute poisoning with bifenthrin on locomotor activity, memory retention, haematological, biochemical and histopathological parameters in miceJ. Physiol. Pharmacol.66(1)129-137(2015)