Bimosiamose (TBC 1269)
(Synonyms: TBC-1269) 目录号 : GC33908
A pan-selectin inhibitor
Cas No.:187269-40-5
Sample solution is provided at 25 µL, 10mM.
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Bimosiamose is a pan-selectin inhibitor (IC50s = 88, 20, and 86 ?M for E-, P-, and L-selectin, respectively).1 It reduces adhesion of HL-60 cells to E- and P-selectin when used at a concentration of 129 ?M.2 In vivo, bimosiamose (200 mg/kg) reduces skin scaliness, induration, and erythema in a patient-derived xenograft mouse model of psoriasis. It decreases hepatic alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and myeloperoxidase (MPO) levels and reduces neutrophil infiltration in a rat model of severe hepatic ischemia-reperfusion injury.1 Bimosiamose also prevents nematode-induced late airway reactivity in sheep and reduces airway hyperresponsiveness in a mouse model of asthma.3
1.Palma-Vargas, J.M., Toledo-Pereyra, L., Dean, R.E., et al.Small-molecule selectin inhibitor protects against liver inflammatory response after ischemia and reperfusionJ. Am. Coll. Surg.185(4)365-372(1997) 2.Friedrich, M., Bock, D., Philipp, S., et al.Pan-selectin antagonism improves psoriasis manifestation in mice and manArch. Dermatol. Res.297(8)345-351(2008) 3.Aydt, E., and Wolff, G.Development of synthetic pan-selectin antagonists: A new treatment strategy for chronic inflammation in asthmaPathobiology70(5)297-301(2002)
| Cas No. | 187269-40-5 | SDF | |
| 别名 | TBC-1269 | ||
| Canonical SMILES | OC[C@H]([C@@H](O)[C@H](O)[C@@H]1O)O[C@@H]1OC(C=C2)=C(C3=CC(CC(O)=O)=CC=C3)C=C2CCCCCCC(C=C4)=CC(C5=CC(CC(O)=O)=CC=C5)=C4O[C@H]6O[C@@H]([C@@H](O)[C@H](O)[C@@H]6O)CO | ||
| 分子式 | C46H54O16 | 分子量 | 862.91 |
| 溶解度 | DMSO: 125 mg/mL (144.86 mM); 0.1 M NaOH: 25 mg/mL (28.97 mM; ultrasonic and adjust pH to 10 with NaOH) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 1.1589 mL | 5.7943 mL | 11.5887 mL |
| 5 mM | 0.2318 mL | 1.1589 mL | 2.3177 mL |
| 10 mM | 0.1159 mL | 0.5794 mL | 1.1589 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet