BMP 6 Human, HEK
目录号 : GP20107Bone Morphogenetic protein-6 Human Recombinant, Hek
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 95.0% as determined by analysis by SDS-PAGE and HPLC analysis. | Source | HEK. |
| Phycical Appearance | Sterile Filtered White lyophilized (freeze-dried) powder. | Shipping Condition | Shipped at Room temp. |
| Synonyms | Bone morphogenetic protein 6; BMP-6; VG-1-related protein; VG-1-R; VGR-1; BMP6; VGR; VGR1. | ||
| Amino Acid Sequence | VSSASDYNSS ELKTACRKHE LYVSFQDLGW QDWIIAPKGY AANYCDGECS FPLNAHMNATNHAIVQTLVH LMNPEYVPKP CCAPTKLNAI SVLYFDDNSN VILKKYRNMV VRACGCH. | ||
| Solubility | It is recommended to reconstitute the lyophilized BMP-6 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. | ||
| Stability | Lyophilized BMP-6 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C . Upon reconstitution BMP-6 should be stored at 4°C between 2-7 days and for future use below -18°C . For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | ||
| Biological Activity | The ED50 as determined by its ability to induce alkaline phosphatase production in the ATDC-5 cell line is typically 0.03-0.06 μg/ml. | ||
| Formulation | The BMP-6 was lyophilized from 10mM Tris, pH 9.0 . | ||
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules, which can induce ectopic bone growth. Various BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were initially identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based upon its expression early in embryogenesis, BMP6 has a suggested role in early development. Moreover, the fact that the BMP6 is closely related to BMP5 and BMP7 leads to an assumption of possible bone inductive activity.
The ED50 as determined by its ability to induce alkaline phosphatase production in the ATDC-5 cell line is typically 0.03-0.06 μg/ml.
Lyophilized BMP-6 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C . Upon reconstitution BMP-6 should be stored at 4°C between 2-7 days and for future use below -18°C . For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.