Bombesin (trifluoroacetate salt)
(Synonyms: Glp-Gln-Arg-LeuGly-Asn-GlnTrp-Ala-ValGly-His-LeuMet-NH2) 目录号 : GC46941
A neuropeptide with diverse biological activities
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Bombesin is a neuropeptide with diverse biological activities originally isolated from the skin of B. bombina and B. variegata variegata amphibians.1,2 It binds to the gastrin-releasing peptide receptor (GRPR) in rat pancreatic acinar cells (Ki = 1.88 nM) and to frog bombesin receptor subtype 4 (BB4) in CHO cells overexpressing the receptor (Ki = 1.7 nM).3 Hypothalamic paraventricular microinfusion of bombesin (100 ng per animal) increases blood glucose, free fatty acids, and corticosterone levels in rats.4 Bombesin (50 ng per animal) injection into the preoptic area decreases food intake by food-deprived or insulin pretreated rats.5 It delays gastric emptying in rats by 55.8% when administered at a dose of 16 μg/kg (i.p.) and inhibits gastric secretion at a dose of 500 ng per animal.6,7
1.Anastasi, A., Erspamer, V., and Bucci, M.Isolation and structure of bombesin and alytesin, two analogous active peptides from the skin of the European amphibians Bombina and AlytesExperientia27(2)166-167(1971) 2.Weber, H.C.Regulation and signaling of human bombesin receptors and their biological effectsCurr. Opin. Endocrinol. Diabetes Obes.16(1)66-71(2009) 3.Pradhan, T.K., Katsuno, T., Taylor, J.E., et al.Identification of a unique ligand which has high affinity for all four bombesin receptor subtypesEur. J. Pharmacol.343(2-3)275-287(1998) 4.Gunion, M.W., TachÉ, Y., Rosenthal, M.J., et al.Bombesin microinfusion into the rat hypothalamic paraventricular nucleus increases blood glucose, free fatty acids and corticosteroneBrain Res.478(1)47-58(1989) 5.Babcock, A.M., Barton, C., Gunion, M.W., et al.Bombesin-induced hypothermia and hypophagia are associated with plasma metabolic fuel alterations in the ratPhysiol. Behav.51(5)933-938(1992) 6.Scarpignato, C., and Bertaccini, G.Bombesin delays gastric emptying in the ratDigestion21(2)104-106(1981) 7.Tache, Y., Lesiege, D., and Goto, Y.Neural pathways involved in intracisternal bombesin-induced inhibition of gastric secretion in ratsDig. Dis. Sci.31(4)412-417(1986)
| Cas No. | N/A | SDF | |
| 别名 | Glp-Gln-Arg-LeuGly-Asn-GlnTrp-Ala-ValGly-His-LeuMet-NH2 | ||
| Canonical SMILES | O=C(N[C@H](C(N[C@@H](C(C)C)C(NCC(N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)CCSC)=O)=O)CC1=CN=CN1)=O)=O)=O)C)[C@@H](NC([C@H](CCC(N)=O)NC([C@H](CC(N)=O)NC(CNC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@@H]2CCC(N2)=O)=O)CCC(N)=O)=O)=O)CC(C)C)=O)=O)=O)=O)CC3=CNC4=C3C=CC=C4.OC(C(F)(F)F)=O | ||
| 分子式 | C71H110N24O18S.XCF3COOH | 分子量 | 1619.9 |
| 溶解度 | Water: 1 mg/ml | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 0.6173 mL | 3.0866 mL | 6.1732 mL |
| 5 mM | 0.1235 mL | 0.6173 mL | 1.2346 mL |
| 10 mM | 0.0617 mL | 0.3087 mL | 0.6173 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。