Bometolol Hydrochloride
(Synonyms: 波美洛尔盐酸盐) 目录号 : GC32665
BometololHydrochloride是一种beta-adrenergic阻滞剂，可用于高血压等心血管疾病的研究。
Cas No.:65023-16-7
Sample solution is provided at 25 µL, 10mM.
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Bometolol Hydrochloride is a beta-adrenergic blocking agent, used for the research of cardiovascular disease.
Bometolol (10-30 mg/kg, p.o.) lowers the blood pressure dose-dependently in spontaneously hypertensive rats, deoxycorticosterone and salt hypertensive rats and two kindey, one clip hypertensive rats. In subchronic study, Bometolol (10-30 mg/kg, or 100-300 mg/kg, p.o.) dose-dependently decreases heart rate, plasma renin activity, heart and kindey weitht and incidence of vascular lesion, but shows no antihypertensive effects in all the hypertensive rats[1].
[1]. Watanabe TX, et al. Acute and subchronic effects of bometolol on blood pressure in hypertensive rats. J Pharmacobiodyn. 1981 Jul;4(7):505-12.
Animal experiment: | Rats[1]In the acute experments, normal female Donryu strain (DON, 14-15 weeks, 250-270 g), and SHR (17-18 weeks, 180-200 g), DOC (7-9 weeks, 180-210 g), and CLIP (7-9 weeks, 180-210 g) hypertensive rats are used. Bometolol hydrochloride is dissolved in H2O and 0.01% Tween 80 solution at a volume of 5 mL/kg body weight for the acute and subchronic studies, respectively. The doses are in terms of the free base. The solution is administratered orally by a gastric tube. In the acute experiment, H2O (5 mL/kg) is giver to the control groups. In the subchronic experment, the drug is administered once a day for 5 weeks, 5 days per week, and Tween 80 solution (5 mL/kg) is given to the control groups[1]. |
References: [1]. Watanabe TX, et al. Acute and subchronic effects of bometolol on blood pressure in hypertensive rats. J Pharmacobiodyn. 1981 Jul;4(7):505-12. | |
| Cas No. | 65023-16-7 | SDF | |
| 别名 | 波美洛尔盐酸盐 | ||
| Canonical SMILES | O=C1NC2=C(C(OCC(O)CNCCC3=CC=C(OC)C(OC)=C3)=CC=C2OCC(C)=O)CC1.[H]Cl | ||
| 分子式 | C25H33ClN2O7 | 分子量 | 508.99 |
| 溶解度 | Soluble in DMSO | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.9647 mL | 9.8234 mL | 19.6468 mL |
| 5 mM | 0.3929 mL | 1.9647 mL | 3.9294 mL |
| 10 mM | 0.1965 mL | 0.9823 mL | 1.9647 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet