BP 554 maleate
目录号 : GC15311
Selective 5-HT1A agonist
Cas No.:82900-57-0
Sample solution is provided at 25 µL, 10mM.
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BP-554 maleate is a selective agonist of 5-HT1A receptor [1].
The 5-HT1A receptor is a G protein-coupled receptor for endogenous neurotransmitter serotonin (5-HT) and mediates inhibitory neurotransmission.
BP-554 maleate is a selective 5-HT1A receptor agonist. BP-554 showed higher affinity for 5-HT1A receptor than for 5-HT1-non-A, 5-HT2, α2-adrenergic, dopamine D2 and benzodiazepine receptors. In rat hippocampal membranes, BP-554 inhibited the activity of adenylate cyclase stimulated by forskolin [1].
In mice, BP-554 inhibited the accumulation of 5-hydroxytryptophan after decarboxylase inhibition and reduced the concentration of 5-hydroxy-indoleacetic acid in the brain. Also, BP-554 increased the levels of serum corticosterone and induced hypothermia [1]. The 5-HT1(A) receptor, 5-HT, brain-derived neurotrophic factor (BDNF) receptor trkB and BDNF formed an auto/paracrine loop to regulate the serotonergic phenotype. In rats, BP-554 dose-dependently increased amounts of neurons expressing serotonergic markers [2]. In monkeys, injection of BP554 into the primary visual cortex decreased multiunit activity (MUA) without influenced blood oxygen-level-dependent (BOLD) and local field potential (LFP) activity [3].
References:
[1]. Matsuda T, Seong YH, Aono H, et al. Agonist activity of a novel compound, 1-[3-(3,4-methylenedioxyphenoxy)propyl]-4-phenyl piperazine (BP-554), at central 5-HT1A receptors. Eur J Pharmacol, 1989, 170(1-2): 75-82.
[2]. Galter D, Unsicker K. Sequential activation of the 5-HT1(A) serotonin receptor and TrkB induces the serotonergic neuronal phenotype. Mol Cell Neurosci, 2000, 15(5): 446-455.
[3]. Rauch A, Rainer G, Logothetis NK. The effect of a serotonin-induced dissociation between spiking and perisynaptic activity on BOLD functional MRI. Proc Natl Acad Sci U S A, 2008, 105(18): 6759-6764.
| Cas No. | 82900-57-0 | SDF | |
| 化学名 | 1-(3-(benzo[d][1,3]dioxol-5-yloxy)propyl)-4-phenylpiperazine maleate | ||
| Canonical SMILES | O=C(O)/C([H])=C([H])\C(O)=O.C1(N2CCN(CC2)CCCOC3=CC4=C(OCO4)C=C3)=CC=CC=C1 | ||
| 分子式 | C20H24N2O3.C4H4O4 | 分子量 | 456.48 |
| 溶解度 | <45.65mg/ml in DMSO | 储存条件 | Store at RT |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.1907 mL | 10.9534 mL | 21.9068 mL |
| 5 mM | 0.4381 mL | 2.1907 mL | 4.3814 mL |
| 10 mM | 0.2191 mL | 1.0953 mL | 2.1907 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet