BPC 157 (acetate)
(Synonyms: GEPPPGKPADDAGLV, Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val) 目录号 : GC46946
A pentadecapeptide with diverse biological activities
Cas No.:1628202-19-6
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Body protection compound 157 (BPC 157) is a pentadecapeptide fragment of BPC that has been found in gastric juice and has diverse biological activities.1 It increases cell migration of, and F-actin formation in, primary rat tendon fibroblasts when used at a concentration of 2 µg/ml.2 BPC 157 (0.01 and 10 µg/kg, i.p.) reduces paw swelling, bone erosion, and inflamed joint mononuclear cell infiltration in a rat model of rheumatoid arthritis induced by complete Freund's adjuvant (CFA).3 It decreases the lesion size of gastric ulcers induced by indomethacin , aspirin , or diclofenac in rats at the same doses. BCP 157 (0.01 and 10 µg/kg, i.p.) decreases the duration of catalepsy and reduces tremor severity in a mouse model of Parkinson's disease induced by MPTP.4
1.Sikiric, P., Seiwerth, S., Rucman, R., et al.Brain-gut axis and pentadecapeptide BPC 157: Theoretical and practical implicationsCurr. Neuropharmacol.14(8)857-865(2016) 2.Chang, C.-H., Tsai, W.-C., Lin, M.-S., et al.The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migrationJ. Appl. Physiol.110(3)774-780(2011) 3.Sikiric, P., Seiwerth, S., Grabarevic, Z., et al.Pentadecapeptide BPC 157 positively affects both non-steroidal anti-inflammatory agent-induced gastrointestinal lesions and adjuvant arthritis in ratsJ. Physiol. (Paris)91(3-5)113-122(1997) 4.Sikiric, P., Marovic, A., Matoz, W., et al.A behavioural study of the effect of pentadecapeptide BPC 157 in Parkinson's disease models in mice and gastric lesions induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridineJ. Physiol. (Paris)93(6)505-512(1999)
| Cas No. | 1628202-19-6 | SDF | |
| 别名 | GEPPPGKPADDAGLV, Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val | ||
| Canonical SMILES | C[C@@H](C(N[C@@H](CC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](C)C(NCC(N[C@@H](CC(C)C)C(N[C@H](C(O)=O)C(C)C)=O)=O)=O)=O)=O)=O)NC([C@@H]1CCCN1C([C@@H](NC(CNC([C@H]2N(C([C@@H]3CCCN3C([C@@H]4CCCN4C([C@@H](NC(CN)=O)CCC(O)=O)=O)=O)=O)CCC2)=O)=O)CCCCN)=O)=O.CC(O)=OC[C@@H](C(N[C@@H](CC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](C)C(NCC(N[C@@H](CC(C)C)C(N[C@H](C(O)=O)C(C)C)=O)=O)=O)=O)=O)=O)NC([C@@H]1CCCN1C([C@@H](NC(CNC([C@H]2N(C([C@@H]3CCCN3C([C@@H]4CCCN4C([C@@H](NC(CN)=O)CCC(O)=O)=O)=O)=O)CCC2)=O)=O)CCCCN)=O)=O.CC(O)=O | ||
| 分子式 | C62H98N16O22.XC2H4O2 | 分子量 | 1419.5 |
| 溶解度 | 储存条件 | Store at -20°C | |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
||
| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 0.7045 mL | 3.5224 mL | 7.0447 mL |
| 5 mM | 0.1409 mL | 0.7045 mL | 1.4089 mL |
| 10 mM | 0.0704 mL | 0.3522 mL | 0.7045 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet