Home>>Peptides>>Bradykinin 1-7 (Bradykinin Fragment 1-​7)

Bradykinin 1-7 (Bradykinin Fragment 1-​7) Sale

(Synonyms: 舒缓激肽片段1-7,Bradykinin Fragment 1-?7) 目录号 : GC32601

缓激肽 1-7(缓激肽片段 1-7)是一种氨基截短的缓激肽。

Bradykinin 1-7 (Bradykinin Fragment 1-​7) Chemical Structure

Cas No.:23815-87-4

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5mg
¥1,339.00
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10mg
¥2,142.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Bradykinin (1-7) is an amino-truncated Bradykinin peptide. Bradykinin (1-7) is a metabolite of Bradykinin, cleaved by endopeptidase.

The Bradykinin peptide system is a tissue-based system with potent cardiovascular and renal effects. To investigate the regulation of this system, a highly sensitive amino terminal-directed radioimmunoassay that, with high performance liquid chromatography, enables the measurement of Bradykinin-(1-7), Bradykinin-(1-8), and Bradykinin-(1-9), is developed. Together with a carboxy terminal-directed radioimmunoassay, Bradykinin peptides in rat kidney and blood are characterized. The predominant Bradykinin peptides in kidney are Bradykinin-(1-9) (~100 fmol/g wet weight of tissue) and Bradykinin-(1-7) (~70 fmol/g), with low levels of Bradykinin-(1-8) (~8 fmol/g) and Bradykinin-(4-9) (~12 fmol/g) detectable; Bradykinin-(2-9) and Bradykinin-(3-9) are below the limits of detection. In blood, the levels of Bradykinin-(1-9) are very low (~2 fmol/ml), and other Bradykinin peptides are below the limits ofdetection. Administration of the angiotensin converting enzyme (ACE) inhibitor Perindopril is associated with an approximate twofold increase in renal levels of Bradykinin-(1-8) and Bradykinin-(1-9) and a decrease in the Bradykinin-(1-7)/Bradykinin-(1-9) ratio. The amino terminal-directed radioimmunoassay is also applied to heart, aorta, brown adipose tissue, adrenal, lung, and brain. For these tissues, Bradykinin-(1-7) and Bradykinin-(1-9) are of similar abundance (16-340 fmol/g), with lower levels of Bradykinin-(1-8)[1].

[1]. Campbell DJ, et al. Bradykinin peptides in kidney, blood, and other tissues of the rat. Hypertension. 1993 Feb;21(2):155-65.

Chemical Properties

Cas No. 23815-87-4 SDF
别名 舒缓激肽片段1-7,Bradykinin Fragment 1-?7
Canonical SMILES Arg-Pro-Pro-Gly-Phe-Ser-Pro
分子式 C35H52N10O9 分子量 756.85
溶解度 H2O : 100 mg/mL (132.13 mM; Need ultrasonic) 储存条件 Store at -20°C
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1 mM 1.3213 mL 6.6063 mL 13.2127 mL
5 mM 0.2643 mL 1.3213 mL 2.6425 mL
10 mM 0.1321 mL 0.6606 mL 1.3213 mL
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