Bradykinin 1-7 (Bradykinin Fragment 1-7)
(Synonyms: 舒缓激肽片段1-7,Bradykinin Fragment 1-?7) 目录号 : GC32601缓激肽 1-7(缓激肽片段 1-7)是一种氨基截短的缓激肽。
Cas No.:23815-87-4
Sample solution is provided at 25 µL, 10mM.
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Bradykinin (1-7) is an amino-truncated Bradykinin peptide. Bradykinin (1-7) is a metabolite of Bradykinin, cleaved by endopeptidase.
The Bradykinin peptide system is a tissue-based system with potent cardiovascular and renal effects. To investigate the regulation of this system, a highly sensitive amino terminal-directed radioimmunoassay that, with high performance liquid chromatography, enables the measurement of Bradykinin-(1-7), Bradykinin-(1-8), and Bradykinin-(1-9), is developed. Together with a carboxy terminal-directed radioimmunoassay, Bradykinin peptides in rat kidney and blood are characterized. The predominant Bradykinin peptides in kidney are Bradykinin-(1-9) (~100 fmol/g wet weight of tissue) and Bradykinin-(1-7) (~70 fmol/g), with low levels of Bradykinin-(1-8) (~8 fmol/g) and Bradykinin-(4-9) (~12 fmol/g) detectable; Bradykinin-(2-9) and Bradykinin-(3-9) are below the limits of detection. In blood, the levels of Bradykinin-(1-9) are very low (~2 fmol/ml), and other Bradykinin peptides are below the limits ofdetection. Administration of the angiotensin converting enzyme (ACE) inhibitor Perindopril is associated with an approximate twofold increase in renal levels of Bradykinin-(1-8) and Bradykinin-(1-9) and a decrease in the Bradykinin-(1-7)/Bradykinin-(1-9) ratio. The amino terminal-directed radioimmunoassay is also applied to heart, aorta, brown adipose tissue, adrenal, lung, and brain. For these tissues, Bradykinin-(1-7) and Bradykinin-(1-9) are of similar abundance (16-340 fmol/g), with lower levels of Bradykinin-(1-8)[1].
[1]. Campbell DJ, et al. Bradykinin peptides in kidney, blood, and other tissues of the rat. Hypertension. 1993 Feb;21(2):155-65.
Cas No. | 23815-87-4 | SDF | |
别名 | 舒缓激肽片段1-7,Bradykinin Fragment 1-?7 | ||
Canonical SMILES | Arg-Pro-Pro-Gly-Phe-Ser-Pro | ||
分子式 | C35H52N10O9 | 分子量 | 756.85 |
溶解度 | H2O : 100 mg/mL (132.13 mM; Need ultrasonic) | 储存条件 | Store at -20°C |
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1 mg | 5 mg | 10 mg | |
1 mM | 1.3213 mL | 6.6063 mL | 13.2127 mL |
5 mM | 0.2643 mL | 1.3213 mL | 2.6425 mL |
10 mM | 0.1321 mL | 0.6606 mL | 1.3213 mL |
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