BRAF Human
目录号 : GP22427B-Raf Proto-Oncogene Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 80.0% as determined by SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile Filtered colorless solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | Proto-Oncogene B-Raf; BRAF1; RAFB1; NS7;EC 2.7.11.1; B-RAF1; P94. | ||
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSEFSEDRN RMKTLGRRDS SDDWEIPDGQ ITVGQRIGSG SFGTVYKGKWHGDVAVKMLN VTAPTPQQLQ AFKNEVGVLR KTRHVNILLF MGYSTKPQLA IVTQWCEGSS LYHHLHIIETKFEMIKLIDI ARQTAQGMDY LHAKSIIHRD LKSNNIFLHE DLTVKIGDFG LATVKSRWSG SHQFEQLSGSILWMAPEVIR MQDKNPYSFQ SDVYAFGIVL YELMTGQLPY SNINNRDQII FMVGRGYLSP DLSKVRSNCPKAMKRLMAEC LKKKRDERPL FPQILASIEL LARSLPKIHR SASEPSLNRA GFQTEDFSLY ACASPKTPIQAGGYGAFPVH. | ||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. | ||
| Formulation | BRAFprotein solution (0.25mg/ml) containing 20mM Tris-HCl (pH8.0) and 10% glycerol. | ||
B-Raf Proto-Oncogene, also known as BRAF is a member of the raf/milfamily of serine/threonine protein kinases. BRAF participates in regulating theMAP kinase/ERKs signaling pathway, which eventually have an effect on celldivision, differentiation, and secretion. Mutations in BRAF have beenassociated with cardiofaciocutaneous syndrome, which is a disease characterizedby heart defects, mental retardation and a distinctive facial appearance. Inaddition, mutations in BRAF have also been associated with different cancers,including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroidcarcinoma, non-small cell lung carcinoma, as well as adenocarcinoma of lung.
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.