Bromacil
(Synonyms: 除草定) 目录号 : GC46949
An herbicide
Cas No.:314-40-9
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Bromacil is a phytotoxic herbicide that inhibits growth of watermelon, molokhia, and wheat plants (EC50s = 4.77, 0.08, and 3.08 mg/kg of soil, respectively).1 It inhibits growth of mustard, pea, sugar beet, linseed, barley, maize, ryegrass, and buckwheat plants by greater than 90% when used at a concentration of 1 kg/hectare.2 In vivo, bromacil induces formation of thyroid tumors in rats and liver tumors in mice.3
1.El-Nahhal, Y., and Hamdona, N.Phytotoxicity of Alachlor, Bromacil and Diuron as single or mixed herbicides applied to wheat, melon, and molokhiaSpringerplus4:367(2015) 2.Cossey, A.L., and Phillips, J.N.3-Alkoxyuracil derivatives. 1. Herbicidal activityJ. Agric. Food Chem.29(4)716-718(1981) 3.Hurley, P.M.Mode of carcinogenic action of pesticides inducing thyroid follicular cell tumors in rodentsEnviron. Health Perspect.106(8)437-445(1998)
| Cas No. | 314-40-9 | SDF | |
| 别名 | 除草定 | ||
| Canonical SMILES | CC(NC1=O)=C(Br)C(N1C(C)CC)=O | ||
| 分子式 | C9H13BrN2O2 | 分子量 | 261.1 |
| 溶解度 | DMSO: Soluble,Methanol: Slightly Soluble | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.83 mL | 19.1498 mL | 38.2995 mL |
| 5 mM | 0.766 mL | 3.83 mL | 7.6599 mL |
| 10 mM | 0.383 mL | 1.915 mL | 3.83 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Degradation of atrazine and Bromacil in two forestry waste products
Sci Rep 2021 Feb 8;11(1):3284.PMID:33558630DOI:10.1038/s41598-021-83052-z.
The persistence and degradation of two common herbicides, atrazine and Bromacil in two organic media, wood pulp and sawdust were compared with two soils. The hypothesis tested was that herbicide degradation will be faster in high organic matter media compared to soil. Degradation of two herbicides was carried out in four different temperature regimes and in sterilised media. The degradation half-life (t½) was determined under above-mentioned conditions then compared to degradation in soil. The degradation as quantified by t½ of the herbicides was generally longer in both organic media. Although microbial degradation was an important factor in the mineralisation of these herbicides, overall, the pH of the media had a more profound effect on the desorption and subsequent degradation rate than the organic carbon content. The results of this study revealed that the hypothesis was only partially correct as organic matter content per se did not strongly relate to degradation rates which were mainly governed by pH and microbial activity.
Movement of Bromacil in a Hawaii soil under pineapple cultivation - a field study
Chemosphere 2008 May;72(1):45-52.PMID:18374966DOI:10.1016/j.chemosphere.2008.02.015.
Recent discovery of low concentrations of Bromacil in drinking water prompted the State of Hawaii to examine the leaching behavior of Bromacil in pineapple fields. This study is a follow up to earlier work on Bromacil concentrations in soil profiles in a pineapple field in central Oahu, Hawaii. Soil samples were collected for Bromacil analysis at different times prior to and after application from a pineapple field that was previously surveyed by other research workers. The leaching pattern of Bromacil was further investigated at two different application rates (2.25 and 1.8 kg ha(-1)). The concentration of Bromacil in the topsoil about 100 days after Bromacil application (1.8 kg ha(-1)) was substantially higher in 2002 compared to 1999. The distribution profiles were generally consistent with the one presented in the previous study. Residual Bromacil was present in the entire sampled zone (3m deep) about 18 months after the previous Bromacil application. Over a period of 9 months, there was substantial dissipation of Bromacil residue present in the topsoil. The residual concentration of Bromacil in the area that received the reduced application rate (1.8 kg ha(-1)) were lower than those receiving the current application rate (2.25 kg ha(-1)) and the depth of penetration of the Bromacil front was shallower at the reduced application rate. Because of the common practice of placing plastic mulch around the base of the pineapple plants to retain volatile nematicides, the applied Bromacil was found to be concentrated in the areas between the plastic mulch, transported by runoff from the plastic. The study results encourage the use of less than the label led rate of application of Bromacil for pineapple fields.
Tolerance and sorption of Bromacil and Paraquat by thermophilic cyanobacteria Leptolyngbya 7M from Costa Rican thermal springs
J Contam Hydrol 2019 Oct;226:103539.PMID:31408829DOI:10.1016/j.jconhyd.2019.103539.
We studied the adsorption ability and tolerance of the thermophilic filamentous cyanobacteria Letolyngbya 7M towards Paraquat and Bromacil. Adsorption isotherms at pH = 7.0 showed an adsorption capacity of 24.4 mg/g and 66.8 mg/g, respectively, and a good fit to the Langmuir model (R2 = 0.97 and 0.99, respectively). To evaluate the effect of both herbicides on photosynthetic pigments and viability of cyanobacteria, cell autoflorescence and esterase activity was determined using flow cytometry. Autofluorescence was less sensitive to changes in cell viability, as it was only slightly reduced at high Paraquat and Bromacil concentrations. Herbicide effect on esterase activity is dose-dependent. Bromacil did not cause a significant effect on either chlorophyll a content or cell viability. This study demonstrates the potential of Leptolyngbya 7M to remove Paraquat and Bromacil herbicides from aqueous solution under laboratory conditions.
Photo-catalysis of Bromacil under simulated solar light using Au/TiO₂: evaluation of main degradation products and toxicity implications
Environ Sci Pollut Res Int 2015 Jan;22(2):1468-79.PMID:25163558DOI:10.1007/s11356-014-3425-3.
Bromacil (5-bromo-3-sec-butyl-6-methyluracil) is a substituted uracil herbicide used worldwide. It is not readily biodegradable and has the potential to contaminate different types of water bodies with possible impact on diverse non-target species. In this work, degradation of Bromacil in aqueous Au/TiO2 suspension under simulated sunlight allowed fourteen degradation products to be identified. The photodegradation of Bromacil followed (pseudo) first order kinetics in the presence of 0.2 g L(-1) of Au/TiO2 with a half-life of 25.66 ± 1.60 min and a rate constant of 0.0271 ± 0.0023 min(-1). Transformation routes of the photo-catalytic degradation of Bromacil were then proposed. Complementary toxicity assessment of the treated Bromacil solution revealed a marked decrease in toxicity, thereby confirming that by-products formed would be less harmful from an environmental point of view. Photo-catalytic degradation of Bromacil thus appears to hold promise as a cost-effective treatment technology to diminish the presence of this herbicide in aquatic systems.
Degradation of Bromacil by a Pseudomonas sp
Appl Environ Microbiol 1988 Sep;54(9):2203-7.PMID:3056270DOI:10.1128/aem.54.9.2203-2207.1988.
A gram-negative rod, identified as a Pseudomonas sp., was isolated from soil by using Bromacil as the sole source of carbon and energy. During growth on Bromacil or 5-bromouracil, almost stoichiometric amounts of bromide were released. The bacterium was shown to harbor two plasmids approximately 60 and 100 kilobases in size. They appeared to be associated with the ability to utilize Bromacil as a sole source of carbon and also with resistance to ampicillin. This microorganism also showed the potential to decontaminate soil samples fortified with Bromacil under laboratory conditions.