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Bromoenol lactone-d7 Sale

(Synonyms: (6E)-Bromoenol lactone-d7) 目录号 : GC46955

A neuropeptide with diverse biological activities

Bromoenol lactone-d7 Chemical Structure

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100 μg
¥496.00
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500 μg
¥2,244.00
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1 mg
¥3,975.00
现货

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Sample solution is provided at 25 µL, 10mM.

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Bromoenol lactone-d7 (BEL-d7) contains seven deuterium atoms at the 2, 3, 4, 5, 6, 7, and 8 positions. It is intended for use as an internal standard for the quantification of BEL by GC- or LC-mass spectrometry (MS). BEL is a selective, potent, irreversible, mechanism-based inhibitor of phospholipase A2 (iPLA2) with a Ki value of 180 nM.1 It also inhibits macrophage iPLA2 in a concentration-dependent manner with an IC50 value of 60 nM and is an effective enzyme-activated irreversible inhibitor of chymotrypsin (Ki = 636 nM).2,3

1.Hazen, S.L., Zupan, L.A., Weiss, R.H., et al.Suicide inhibition of canine myocardial cytosolic calcium-independent phospholipase A2The Journal of Biological Chemisty2667227-7232(1991) 2.Ackermann, E.J., Conde-Frieboes, K., and Dennis, E.A.Inhibition of macrophage Ca2+-independent phospholipase A2 by bromoenol lactone and trifluoromethyl ketonesThe Journal of Biological Chemisty270445-450(1995) 3.Balsinde, J., Bianco, I.D., Ackermann, E.J., et al.Inhibition of calcium-independent phospholipase A2 prevents arachidonic acid incorporation and phospholipid remodeling in P388D1 macrophagesProceedings of the National Academy of Sciences of the United States of America928527-8531(1995)

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1 mg 5 mg 10 mg
1 mM 3.0845 mL 15.4226 mL 30.8452 mL
5 mM 0.6169 mL 3.0845 mL 6.169 mL
10 mM 0.3085 mL 1.5423 mL 3.0845 mL
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