Bromopride
(Synonyms: 溴必利；溴灭吐灵) 目录号 : GC31047
A dopamine D2 receptor antagonist
Cas No.:4093-35-0
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Bromopride is a dopamine D2 receptor antagonist (Ki = 14 nM).1 It binds to bovine anterior pituitary membranes with an IC50 value of 2.13 μM.2 Bromopride inhibits cholinesterase activity in vitro in rat plasma and striatum homogenate (IC50s = 67.8 and 38.4 μM, respectively).3 It increases serum prolactin levels in rats by 100% when used at a dose of 0.02 mol/kg.2 Bromopride (2.5 mg/kg) decreases locomotion and rearing in an open field test and impairs acquistion, but not retention, of a conditioned avoidance response in a two-way active conditioned avoidance test in rats.4
1.Tonini, M., Cipollina, L., Poluzzi, E., et al.Clinical implications of enteric and central D2 receptor blockade by antidopaminergic gastrointestinal prokineticsAliment. Pharmacol. Ther.19(4)379-390(2004) 2.Meltzer, H.Y., Simonovic, M., and So, R.Effects of a series of substituted benzamides on rat prolactin secretion and 3H-spiperone binding to bovine anterior pituitary membranesLife Sci.32(25)2877-2886(1983) 3.Nasello, A.G., Gidali, D., de Sá-Rocha, L.C., et al.Differential effects of bromopride and domperidone on cholinesterase activity in rat tissuesLife Sci.56(3)151-156(1995) 4.Nasello, A.G., Vanzeler, M.L., and Felicio, L.F.A comparison of bromopride and domperidone effects on rat conditioned avoidance and motor activityPharmacol. Toxicol.68(1)46-50(1991)
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 2.9049 mL | 14.5243 mL | 29.0487 mL |
| 5 mM | 0.581 mL | 2.9049 mL | 5.8097 mL |
| 10 mM | 0.2905 mL | 1.4524 mL | 2.9049 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。