Butyl isobutyl phthalate
(Synonyms: 邻苯二甲酸-1-丁酯-2-异丁酯) 目录号 : GC39233
Butyl isobutyl phthalate (BIP), isolated from the rhizoid of Laminaria japonica, is a non-competitive inhibitor of α-glucosidase with IC50 of 38 μM. Butyl isobutyl phthalate displays a significant hypoglycemic effect and has the potential for diabetes treatment.
Cas No.:17851-53-5
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >97.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Butyl isobutyl phthalate (BIP), isolated from the rhizoid of Laminaria japonica, is a non-competitive inhibitor of α-glucosidase with IC50 of 38 μM. Butyl isobutyl phthalate displays a significant hypoglycemic effect and has the potential for diabetes treatment.
[1] Tong Bu, et al. Phytother Res. 2010 Nov;24(11):1588-91.
| Cas No. | 17851-53-5 | SDF | |
| 别名 | 邻苯二甲酸-1-丁酯-2-异丁酯 | ||
| Canonical SMILES | O=C(C1=CC=CC=C1C(OCC(C)C)=O)OCCCC | ||
| 分子式 | C16H22O4 | 分子量 | 278.34 |
| 溶解度 | DMSO: ≥ 250 mg/mL (898.18 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.5927 mL | 17.9636 mL | 35.9273 mL |
| 5 mM | 0.7185 mL | 3.5927 mL | 7.1855 mL |
| 10 mM | 0.3593 mL | 1.7964 mL | 3.5927 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Plant growth promoting potential of Butyl isobutyl phthalate and Streptomyces sp. from Rumex dentatus on rice
Appl Microbiol Biotechnol 2022 Apr;106(7):2603-2617.PMID:35262787DOI:10.1007/s00253-022-11862-w.
Rice (Oryza sativa L.) is one of the most important staple foods consumed in many countries of the world. It is mostly consumed in developing countries where different chemical fertilizers are used to improve the productivity of the crop plant. In the present study, endophytic actinomycetes isolated from Rumex dentatus were identified morphologically and by scanning electron microscopy. Butyl isobutyl phthalate (BIBP) was isolated from the root endophyte Streptomyces sp. JR9 using column chromatography and HPLC methods. The compound was tested for its effect on rice seed germination. BIBP, extracts, and isolates were evaluated for their plant growth effect on rice in a growth chamber. Isolates were also screened in vitro for phosphate solubilization activity and enzyme production. Indole-3-acetic acid (IAA) and BIBP produced in extracts were quantified and detected using high performance liquid chromatography (HPLC) and liquid chromatography-mass spectrometry (LC-MS) methods, respectively. BIBP was found to increase the germination of rice seeds by 6 to 12% in treated samples and displayed potent effect at lowest concentration (0.437 µM). Both the compound and the extract depicted significant increases in almost all growth parameters at lowest concentration of 0.125 µg/mL and 62.5 µg/mL, respectively. BIBP also increased significantly shoot length, fresh root, fresh shoot, and dried shoot weight at high concentrations and was more potent than the standard phytohormone IAA. HPLC quantification showed 7.952 µg/mg and 0.371 µg/mg of IAA in extracts of Streptomyces sp. JR9 and the stem endophyte Streptomyces sp. KS3, respectively. IAA containing extract of JR9 increased significantly most growth parameters at lowest concentration (125 µg/mL). The extract of KS3 depicted significant increases in almost all growth parameters at high concentration (500 µg/mL). Our investigation showed that streptomycetes isolated from R. dentatus and BIBP are potent growth promoting agents and can be used in agriculture as bio-fertilizer to improve the growth and productivity of rice. KEY POINTS: • Butyl isobutyl phthalate (BIBP) isolated from endophytic Streptomyces sp. JR9 is a potent rice seed germination activator and promotes significantly the growth of rice • Isolated endophytes showed the ability to produce enzymes and phytohormone IAA • Isolates enhanced significantly the growth of rice.
Ameliorating effects of water bamboo shoot (Zizania latifolia) on acute alcoholism in a mice model and its chemical composition
Food Chem 2022 Jun 1;378:132122.PMID:35033708DOI:10.1016/j.foodchem.2022.132122.
In this study, the ameliorative effect of water bamboo shoot (WBS) on acute alcoholism mice was investigated and potential biological compounds were explored. Results showed that extraction methods significantly affected the active substances contents and bioactivities of WBS. Principal component analysis (PCA) showed that alkali extract (NE) obtained the highest score, therefore, it was selected for further analysis. Animal experiments showed that NE demonstrated ameliorative effects on acute alcoholism mice as evident by significantly elevated activities of dehydrogenase (alcohol dehydrogenase, acetaldehyde dehydrogenase) and antioxidant enzymes (superoxide dismutase, glutathione peroxidase, catalase), whereas significantly reduced the levels of aminotransferase (alanine aminotransferase, aspartate aminotransferase) in serum. The potential bioactive activity compounds of NE were explored by UPLC-MS/MS and bioinformatics analysis. Butyl isobutyl phthalate vanillin, ferulic acid methyl ester might be the major compounds in NE on alleviating acute alcoholism. These results indicated that WBS possesses potential ameliorating effect on acute alcoholism.
[Chemical Constituents from Dalbergia cochinchinensis]
Zhong Yao Cai 2015 Sep;38(9):1868-71.PMID:26930980doi
Objective: To investigate the chemical constituents from the heartwood of Dalbergia cochinchinensis. Methods: Isolate and purify compounds by various column chromatographic methods. Spectral analysis were taken to identify the structures. Results: Elev- en compounds were isolated and identified as dibutyl terephthalate (1), medicarpin (2), pterostilbene (3), 6-hydroxy-2-(2-hydroxy-4- methoxyphenyl)-benzofuran (4), pterocarpol (5), Butyl isobutyl phthalate (6), pterolinus B (7), methyl 4-hydroxybenzoate (8), ethyl 4- hydroxybenzoate (9),2-(2'-methoxy-4'-hydroxy)-aryl-3-methyl-6-hydroxy-benzofuran (10) and 6α-hydroxycyclonerolidol (11). Conclusion: Compounds 1 and 6~10 are isolated from Dalbergia genus for the first time, and compounds 2, 4 and 11 are isolated from this plant for the first time.
Novel bioactive molecules from Lentzea violacea strain AS 08 using one strain-many compounds (OSMAC) approach
Bioorg Med Chem Lett 2017 Jun 1;27(11):2579-2582.PMID:28400238DOI:10.1016/j.bmcl.2017.03.075.
A new eudesmane sesquiterpenoid (1), and a new homologue of virginiae butanolide E (2) along with Butyl isobutyl phthalate (3) were isolated from, actinomycete-Lentzea violacea strain AS08 isolated from north western Himalayas by stressing on modified one strain-many compounds (OSMAC) method. The structures of the new compounds were elucidated by extensive spectroscopic analyses including 1D, 2D NMR along with HR-ESI-MS and FT-IR data. Herein, a distinctive method was added for inspecting secretory profile of the strain by quantification of extract value of cell free supernatant in different types of culture media fallowed by HPLC profiling of respective extracts, which revealed a highly altered metabolic profile of the strain and formed the base for the selection of media. The compounds 1 and 2 showed moderate activity against Gram negative (MIC ∼32-64µgml-1) in comparison to Gram positive bacterial pathogens. Compound 1 exhibited significant activity in human cancerous cell lines (IC50 ∼19.2µM).
[Constituents in petroleum ether and ethyl acetate extract fractions of Dracaena cochinensis (Lour.) S.C. Chen]
Zhongguo Zhong Yao Za Zhi 1998 Oct;23(10):616-8, 640.PMID:11599361doi
Objective: To study the chemical constituents of Dracaena cochinensis. Methods: Compounds were separated by solvent extraction, column chromatography, TLC and HPLC, and their structures were determined by spectral analysis. Results: Ten compounds were isolated from the petroleum ether and ethyl acetate fractions of D. cochinensis and identified as n-heptacosane, lophenol, docosanyl ferulate, tetracosanyl ferulate, hexacosanyl ferulate, octacosanyl ferulate, pterostilbene, dioctyl phthalate, Butyl isobutyl phthalate and 4'-methoxy-3',7-dihydroxy-flavone. Conclusion: All the compounds were isolated from this plant for the first time.