Butylparaben (Butyl parahydroxybenzoate)
(Synonyms: 对羟基苯甲酸丁酯; Butyl parahydroxybenzoate; Butyl paraben; Butyl 4-hydroxybenzoate) 目录号 : GC32255
A paraben
Cas No.:94-26-8
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Butyl 4-hydroxybenzoate is a paraben that has been found in Microbulbifer.1 It is active against the Gram-positive bacteria B. subtilis and S. aureus, yeast C. molischiana and S. cerevisiae, and fungi A. niger and P. chrysogenum (MICs = 75, 75, 60, 52, 55, and 45 mg/L, respectively). Butyl 4-hydroxybenzoate (300-1,000 ?M) decreases the viability of, and ATP and glutathione (GSH) levels in, HepG2 and human dermal fibroblast neonatal (HDFn) cells.2 It binds to estrogen receptors in a concentration-dependent manner and increases uterine weight in immature and ovariectomized rats.3 Butyl 4-hydroxybenzoate has been found in influent and effluent wastewater.4 Formulations containing butyl 4-hydroxybenzoate have been used as preservatives in cosmetics, food, and pharmaceuticals.
1.Peng, X., Adachi, K., Chen, C., et al.Discovery of a marine bacterium producing 4-hydroxybenzoate and its alkyl esters, parabensAppl. Environ. Microbiol.72(8)5556-5561(2006) 2.Kizhedath, A., Wilkinson, S., and Glassey, J.Assessment of hepatotoxicity and dermal toxicity of butyl paraben and methyl paraben using HepG2 and HDFn in vitro modelsToxicol. In Vitro55108-115(2019) 3.Routledge, E.J., Parker, J., Odum, J., et al.Some alkyl hydroxy benzoate preservatives (parabens) are estrogenicToxicol. Appl. Pharmacol.153(1)12-19(1998) 4.Wang, W., and Kannan, K.Fate of parabens and their metabolites in two wastewater treatment plants in New York state, United StatesEnviron. Sci. Technol.50(3)1174-1181(2016)
| Cas No. | 94-26-8 | SDF | |
| 别名 | 对羟基苯甲酸丁酯; Butyl parahydroxybenzoate; Butyl paraben; Butyl 4-hydroxybenzoate | ||
| Canonical SMILES | O=C(OCCCC)C1=CC=C(O)C=C1 | ||
| 分子式 | C11H14O3 | 分子量 | 194.23 |
| 溶解度 | Insoluble in Water; ≥116.2 mg/mL in DMSO; ≥47.2 mg/mL in EtOH | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 5.1485 mL | 25.7427 mL | 51.4854 mL |
| 5 mM | 1.0297 mL | 5.1485 mL | 10.2971 mL |
| 10 mM | 0.5149 mL | 2.5743 mL | 5.1485 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Photo-degradation of Butyl parahydroxybenzoate by using TiO2-supported catalyst
Water Sci Technol 2013;67(10):2141-7.PMID:23676380DOI:10.2166/wst.2013.117
The present work evaluates the potential of the photocatalysis (PC) process for the degradation of Butylparaben (BPB). Relatively high treatment efficiency was achieved by comparison to photochemical process. Prior to photocatalytic degradation, adsorption (AD) of BPB occurred on the titanium dioxide (TiO2)-supported catalyst. AD was described by Langmuir isotherm (KL = 0.085 L g(-1), qm = 4.77 mg g(-1)). The influence of angle of inclination of the reactor, pH, recirculation flow rate and initial concentration of BPB were investigated. The PC process applied under optimal operating conditions (recirculation flow rate of 0.15 L min(-1), angle of inclination of 15掳, pH = 7 and 5 mg L(-1) of BPB) is able to oxidize 84.9-96.6% of BPB and to ensure around 38.7% of mineralization. The Langmuir-Hinshelwood kinetic model described well the photocatalytic oxidation of BPB (k = 7.02 mg L(-1) h(-1), K = 0.364 L mg(-1)).