Butylparaben (Butyl parahydroxybenzoate)
(Synonyms: 对羟基苯甲酸丁酯; Butyl parahydroxybenzoate; Butyl paraben; Butyl 4-hydroxybenzoate) 目录号 : GC32255
A paraben
Cas No.:94-26-8
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Butyl 4-hydroxybenzoate is a paraben that has been found in Microbulbifer.1 It is active against the Gram-positive bacteria B. subtilis and S. aureus, yeast C. molischiana and S. cerevisiae, and fungi A. niger and P. chrysogenum (MICs = 75, 75, 60, 52, 55, and 45 mg/L, respectively). Butyl 4-hydroxybenzoate (300-1,000 ?M) decreases the viability of, and ATP and glutathione (GSH) levels in, HepG2 and human dermal fibroblast neonatal (HDFn) cells.2 It binds to estrogen receptors in a concentration-dependent manner and increases uterine weight in immature and ovariectomized rats.3 Butyl 4-hydroxybenzoate has been found in influent and effluent wastewater.4 Formulations containing butyl 4-hydroxybenzoate have been used as preservatives in cosmetics, food, and pharmaceuticals.
1.Peng, X., Adachi, K., Chen, C., et al.Discovery of a marine bacterium producing 4-hydroxybenzoate and its alkyl esters, parabensAppl. Environ. Microbiol.72(8)5556-5561(2006) 2.Kizhedath, A., Wilkinson, S., and Glassey, J.Assessment of hepatotoxicity and dermal toxicity of butyl paraben and methyl paraben using HepG2 and HDFn in vitro modelsToxicol. In Vitro55108-115(2019) 3.Routledge, E.J., Parker, J., Odum, J., et al.Some alkyl hydroxy benzoate preservatives (parabens) are estrogenicToxicol. Appl. Pharmacol.153(1)12-19(1998) 4.Wang, W., and Kannan, K.Fate of parabens and their metabolites in two wastewater treatment plants in New York state, United StatesEnviron. Sci. Technol.50(3)1174-1181(2016)
| Cas No. | 94-26-8 | SDF | |
| 别名 | 对羟基苯甲酸丁酯; Butyl parahydroxybenzoate; Butyl paraben; Butyl 4-hydroxybenzoate | ||
| Canonical SMILES | O=C(OCCCC)C1=CC=C(O)C=C1 | ||
| 分子式 | C11H14O3 | 分子量 | 194.23 |
| 溶解度 | Insoluble in Water; ≥116.2 mg/mL in DMSO; ≥47.2 mg/mL in EtOH | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
||
| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 5.1485 mL | 25.7427 mL | 51.4854 mL |
| 5 mM | 1.0297 mL | 5.1485 mL | 10.2971 mL |
| 10 mM | 0.5149 mL | 2.5743 mL | 5.1485 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet