BW 723C86 hydrochloride
(Synonyms: BW723C86盐酸盐) 目录号 : GC11231A selective HT2B receptor agonist
Cas No.:160521-72-2
Sample solution is provided at 25 µL, 10mM.
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BW 723C86 hydrochloride is a selective agonist of 5-HT2B receptor [1].
The 5-HT2B receptor is a G protein-coupled receptor for endogenous neurotransmitter serotonin (5-HT) and plays an important role in shape changes in platelets, contraction of blood vessels and neuronal sensitization to tactile stimuli.
BW 723C86 hydrochloride is a selective 5-HT2B receptor agonist. BW723C86 reversibly increased both the amplitude and frequency of miniature excitatory postsynaptic currents (mEPSCs) in cardiac vagal neurons (CVNs), which were blocked by P2 receptor antagonist PPADS. And BW723C86 facilitated excitatory purinergic neurotransmission to CVNs via P2X receptor [2].
In a rat social interaction test, BW 723C86 (3 or 10 mg/kg) increased total interaction and induced an anxiolytic-like action, which was mediated by 5-HT2B receptor [1]. In a rat Vogel conflict test, BW 723C86 (10 or 30 mg/kg) increased the number of punishments, which were mediated by 5-HT2B receptor and were consistent with its anxiolytic-like properties [3]. In a neuropathic pain rat model, BW723C86 significantly inhibited mechanical allodynia and cold allodynia in a dose-dependent way [4].
References:
[1]. Kennett GA, Bright F, Trail B, et al. Effects of the 5-HT2B receptor agonist, BW 723C86, on three rat models of anxiety. Br J Pharmacol, 1996, 117(7): 1443-1448.
[2]. Dergacheva O, Wang X, Kamendi H, et al. 5HT2 receptor activation facilitates P2X receptor mediated excitatory neurotransmission to cardiac vagal neurons in the nucleus ambiguus. Neuropharmacology, 2008, 54(7): 1095-1102.
[3]. Kennett GA, Trail B, Bright F. Anxiolytic-like actions of BW 723C86 in the rat Vogel conflict test are 5-HT2B receptor mediated. Neuropharmacology, 1998, 37(12): 1603-1610.
[4]. Urtikova N, Berson N, Van Steenwinckel J, et al. Antinociceptive effect of peripheral serotonin 5-HT2B receptor activation on neuropathic pain. Pain, 2012, 153(6): 1320-1331.
| Cas No. | 160521-72-2 | SDF | |
| 别名 | BW723C86盐酸盐 | ||
| 化学名 | (R)-1-(5-(thiophen-2-ylmethoxy)-1H-indol-3-yl)propan-2-amine hydrochloride | ||
| Canonical SMILES | N[C@H](C)CC(C1=C2)=CNC1=CC=C2OCC3=CC=CS3.Cl | ||
| 分子式 | C16H18N2OS.HCl | 分子量 | 322.85 |
| 溶解度 | DMF: >55 mg/ml,DMSO: >52 mg/ml,Ethanol: >6 mg/ml,PBS pH 7.2: >160 µ g/ml | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.0974 mL | 15.4871 mL | 30.9741 mL |
| 5 mM | 0.6195 mL | 3.0974 mL | 6.1948 mL |
| 10 mM | 0.3097 mL | 1.5487 mL | 3.0974 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet