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BX-320 Sale

(Synonyms: N1-[3-[[5-溴-2-[[3-[(1-吡咯烷基羰基)氨基]苯基]氨基]-4-嘧啶基]氨基]丙基]-2,2-二甲基丙烷二酰胺) 目录号 : GC48433

An inhibitor of PDK1

BX-320 Chemical Structure

Cas No.:702676-93-5

规格 价格 库存 购买数量
500µg
¥770.00
现货
1mg
¥1,165.00
现货
5mg
¥4,625.00
现货

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产品描述

BX-320 is an inhibitor of the serine/threonine kinase 3-phosphoinositide-dependent protein kinase 1 (PDK1; IC50 = 30 nM).1 It is selective for PDK1 over a panel of 10 additional kinases (IC50s = >820 nM for all). BX-320 inhibits Akt and p70S6K1 phosphorylation in PC3 cells (IC50s = 1-3 µM). It induces apoptosis in, and inhibits the growth of, MDA-MB-468 breast cancer cells (IC50s = 0.5 and 0.6 µM, respectively), as well as inhibits cell growth in a panel of cancer cells (IC50s = 0.12-1.2 µM). BX-320 (200 mg/kg) inhibits the growth of lung tumors in a LOX melanoma mouse model of blood-borne metastasis.

1.Feldman, R.I., Wu, J.M., Polokoff, M.A., et al.Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1J. Biol. Chem.280(20)19867-19874(2005)

Chemical Properties

Cas No. 702676-93-5 SDF
别名 N1-[3-[[5-溴-2-[[3-[(1-吡咯烷基羰基)氨基]苯基]氨基]-4-嘧啶基]氨基]丙基]-2,2-二甲基丙烷二酰胺
Canonical SMILES O=C(N1CCCC1)NC2=CC(NC3=NC(NCCCNC(C(C)(C)C(N)=O)=O)=C(Br)C=N3)=CC=C2
分子式 C23H31BrN8O3 分子量 547.5
溶解度 DMSO: soluble 储存条件 -20°C
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1 mg 5 mg 10 mg
1 mM 1.8265 mL 9.1324 mL 18.2648 mL
5 mM 0.3653 mL 1.8265 mL 3.653 mL
10 mM 0.1826 mL 0.9132 mL 1.8265 mL
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Research Update

Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1

J Biol Chem 2005 May 20;280(20):19867-74.PMID:15772071DOI:10.1074/jbc.M501367200

The phosphoinositide 3-kinase/3-phosphoinositide-dependent kinase 1 (PDK1)/Akt signaling pathway plays a key role in cancer cell growth, survival, and tumor angiogenesis and represents a promising target for anticancer drugs. Here, we describe three potent PDK1 inhibitors, BX-795, BX-912, and BX-320 (IC(50) = 11-30 nm) and their initial biological characterization. The inhibitors blocked PDK1/Akt signaling in tumor cells and inhibited the anchorage-dependent growth of a variety of tumor cell lines in culture or induced apoptosis. A number of cancer cell lines with elevated Akt activity were >30-fold more sensitive to growth inhibition by PDK1 inhibitors in soft agar than on tissue culture plastic, consistent with the cell survival function of the PDK1/Akt signaling pathway, which is particularly important for unattached cells. BX-320 inhibited the growth of LOX melanoma tumors in the lungs of nude mice after injection of tumor cells into the tail vein. The effect of BX-320 on cancer cell growth in vitro and in vivo indicates that PDK1 inhibitors may have clinical utility as anticancer agents.