C18 Ganglioside GM3-d3 (d18:1/18:0-d3) (ammonium salt, synthetic)
(Synonyms: C18 GM3-d3, N-ω-CD3-Octadecanoyl monosialoganglioside GM3, Monosialoganglioside GM3-d3, N-Stearoyl Monosialoganglioside GM3-d3) 目录号 : GC91123一种用于量化神经节苷脂GM3的内部标准。
Cas No.:2692623-85-9
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
C18 Ganglioside GM3-d3 (d18:1/18:0-d3) is intended for use as an internal standard for the quantification of ganglioside GM3 by GC- or LC-MS. Ganglioside GM3 is a simple monosialoganglioside that demonstrates both antiproliferative and proapoptotic effects in tumor cells by modulating cell adhesion, proliferation, and differentiation.1,2 When used at a concentration of 20 μM, it suppresses angiogenesis and reduces endothelial cell proliferation and migration by inhibiting VEGFR2 and Akt phosphorylation.1 Furthermore, ganglioside GM3 has been shown to induce the dissociation of the insulin receptor-caveolin-1 complex from lipid microdomains, functioning as an inhibitor of insulin signaling and contributing to insulin resistance.3
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 0.8322 mL | 4.1611 mL | 8.3222 mL |
| 5 mM | 0.1664 mL | 0.8322 mL | 1.6644 mL |
| 10 mM | 0.0832 mL | 0.4161 mL | 0.8322 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。