C18 Ganglioside GM3-d3 (d18:1/18:0-d3) (ammonium salt)
(Synonyms: C18 GM3-d3, Monosialoganglioside GM3-d3, N-Stearoyl Monosialoganglioside GM3-d3, N-omega-CD3-Octadecanoyl monosialoganglioside GM3) 目录号 : GC46994A neuropeptide with diverse biological activities
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
C18 Ganglioside GM3-d3 is intended for use as an internal standard for the quantification of ganglioside GM3 by GC- or LC-MS. Ganglioside GM3 is a simple monosialoganglioside that demonstrates both antiproliferative and proapoptotic effects in tumor cells by modulating cell adhesion, proliferation, and differentiation.1,2 When used at a concentration of 20 μM, it suppresses angiogenesis and reduces endothelial cell proliferation and migration by inhibiting VEGFR2 and Akt phosphorylation.1 Furthermore, ganglioside GM3 has been shown to induce the dissociation of the insulin receptor-caveolin-1 complex from lipid microdomains, functioning as an inhibitor of insulin signaling and contributing to insulin resistance.3 [Matreya, LLC. Catalog No. 2052]
1.Mukherjee, P., Faber, A.C., Shelton, L.M., et al.Thematic review series: Sphingolipids. Ganglioside GM3 suppresses the proangiogenic effects of vascular endothelial growth factor and ganglioside GD1aJ. Lipid Res.49(5)929-938(2008) 2.Seyfried, T.N., and Mukherjee, P.Ganglioside GM3 is antiangiogenic in malignant brain cancerJ. Oncol.961243(2010) 3.Kabayama, K., Sato, T., Saito, K., et al.Dissociation of the insulin receptor and caveolin-1 complex by ganglioside GM3 in the state of insulin resistanceProc. Natl. Acad. Sci. USA104(34)13678-13683(2007)
| Cas No. | N/A | SDF | |
| 别名 | C18 GM3-d3, Monosialoganglioside GM3-d3, N-Stearoyl Monosialoganglioside GM3-d3, N-omega-CD3-Octadecanoyl monosialoganglioside GM3 | ||
| Canonical SMILES | OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@@]2([H])[C@@H]([C@@]([C@H]([C@H](O2)CO)O)([H])O[C@]3(C([O-])=O)C[C@H](O)[C@@H](NC(C)=O)[C@H]([C@@H]([C@H](O)CO)O)O3)O)O[C@H]1OC[C@@H]([C@H](O)/C=C/CCCCCCCCCCCCC)NC(CCCCCCCCCCCCCCCCC([2H])([2H])[2H])=O.[NH4+] | ||
| 分子式 | C59H104D3N2O21.NH4 | 分子量 | 1201.5 |
| 溶解度 | Chloroform:Methanol:Water (2:1:0.1): Soluble | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
||
| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 0.8323 mL | 4.1615 mL | 8.3229 mL |
| 5 mM | 0.1665 mL | 0.8323 mL | 1.6646 mL |
| 10 mM | 0.0832 mL | 0.4161 mL | 0.8323 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。