CADM1 Human
目录号 : GP22950Cell Adhesion Molecule 1 Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 85.0% as determined by SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile Filtered colorless solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | Cell Adhesion Molecule 1; Tumor Suppressor In Lung Cancer1; IGSF4; Spermatogenic Immunoglobulin Superfamily; Immunoglobulin Superfamily;Member 4; Immunoglobulin Superfamily Member 4; Synaptic Cell Adhesion Molecule;Nectin-Like Protein 2; Nectin-Like 2; Necl-2; SgIGSF; IGSF4A; SYNCAM; TSLC-1;TSLC1; NECL2; Immunoglobulin Superfamily; Member 4D Variant 1; Immunoglobulin Superfamily;Member 4D Variant 2; TSLC1/Nectin-Like 2/IGSF4; Truncated CADM1 Protein;STSLC-1; SynCAM1; RA175; ST17; BL2; Cell adhesion molecule 1. | ||
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSQNLFTKD VTVIEGEVAT ISCQVNKSDD SVIQLLNPNR QTIYFRDFRPLKDSRFQLLN FSSSELKVSL TNVSISDEGR YFCQLYTDPP QESYTTITVL VPPRNLMIDI QKDTAVEGEEIEVNCTAMAS KPATTIRWFK GNTELKGKSE VEEWSDMYTVTSQLMLKVHK EDDGVPVICQ VEHPAVTGNL QTQRYLEVQY KPQVHIQMTYPLQGLTREGD ALELTCEAIG KPQPVMVTWV RVDDEMPQHA VLSGPNLFIN NLNKTDNGTY RCEASNIVGKAHSDYMLYVY DPPTTIPPPT TTTTTTTTTT TTILTIITDS RAGEEGSIRA VDH. | ||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. | ||
| Formulation | CADM1 protein solution (0.25 mg/ml) containing Phosphatebuffered saline (pH7.4), 10% glycerol and 1mM DTT. | ||
Cell Adhesion Molecule 1, also known as CADM1 belongs to the nectin family. CADM1 mediates homophilic cell-cell adhesion in a Ca2+-independent manner as well as mediating heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca2+-independent manner.Furthermore, CADM1 perform as a tumor suppressor in non-small-cell lung cancer, NSCLC, cells. The interaction with CRTAM promotes natural killer (NK) cell cytotoxicity & IFN-gamma secretion by CD8+ cells in vitro over and above NK cell-mediated rejection of tumors expressing CADM3 in vivo.
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.