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目录号 : GC31703

CAM-IN-1 是一种有效的选择性 E-selectin 和 ICAM-1 抑制剂,IC50 值分别为 7 和 5 nM。

CAM-IN-1 Chemical Structure

Cas No.:251994-14-6

规格 价格 库存 购买数量
1mg
¥1,714.00
现货
5mg
¥4,500.00
现货
10mg
¥7,650.00
现货
20mg
¥10,282.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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实验参考方法

Animal experiment:

Rats: In a rat rheumatoid arthritis model, 26 all rats are treated with peptidoglycan polysaccharide to elicit the disease to a desired degree. Six rats per group are then treated with ICAM-1-IN-1 or vehicle control twice daily. The ankles of these rats are measured on day 0, 1, 3, 7, 9, 11, 16, 18, and 21 after administration. Histologic analyses of the ankles are performed on the last day of the experiment[1].

References:

[1]. Zhu GD, et al. Selective inhibition of ICAM-1 and E-selectin expression in human endothelial cells. 2. Arylmodifications of 4-(aryloxy)thieno[2,3-c]pyridines with fine-tuning at C-2 carbamides. J Med Chem. 2001 Oct 11;44(21):3469-87.

产品描述

CAM-IN-1 is a potent and selective inhibitor of E-selectin and ICAM-1 with IC50 values of 7 and 5 nM, respectively.

CAM-IN-1 shows significant efficacy in a rat rheumatoid arthritis model and in a mouse asthma model. CAM-IN-1 reduces the width of inflamed ankles after the ninth day following treatment, but shows no efficacy in the acute phase. Treatment with CAM-IN-1 (25 mg/kg) for 21 days significantly reduces the ankle inflammation of the arthritis rats. Significant reduction of eosinophils and serum-soluble ICAM-1 (sICAM-1) is observed[1].

[1]. Zhu GD, et al. Selective inhibition of ICAM-1 and E-selectin expression in human endothelial cells. 2. Arylmodifications of 4-(aryloxy)thieno[2,3-c]pyridines with fine-tuning at C-2 carbamides. J Med Chem. 2001 Oct 11;44(21):3469-87.

Chemical Properties

Cas No. 251994-14-6 SDF
Canonical SMILES O=C(C(S1)=CC2=C1C=NC=C2OC3=CC=C(Br)C=C3)NC
分子式 C15H11BrN2O2S 分子量 363.23
溶解度 DMSO : ≥ 135 mg/mL (371.67 mM) 储存条件 Store at -20°C
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.7531 mL 13.7654 mL 27.5308 mL
5 mM 0.5506 mL 2.7531 mL 5.5062 mL
10 mM 0.2753 mL 1.3765 mL 2.7531 mL
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