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Candoxatril (UK 79300) Sale

(Synonyms: 坎沙曲,UK 79300) 目录号 : GC31608

Candoxatril (UK 79300) 是一种中性肽链内切酶 (NEP) 抑制剂。

Candoxatril (UK 79300) Chemical Structure

Cas No.:123122-55-4

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500mg 待询 待询

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Description

Candoxatril is a neutral endopeptidase (NEP) inhibitor.

While the NEP inhibitors have no significant effect on body weight, food and water intake, mean blood pressure or creatinine levels, they do increase cGMP levels in the urine and affected hematopoiesis in an anti-inflammatory way. Moreover, a-SMA deposition in the kidney cortex is inversely correlated with cGMP elevation suggesting a NEP dependent antifibroti effect. High quality mRNA profiles are obtained with at least 8 independent samples per treatment group. The data confirms the cGMP dependent anti-fibrotic action of Sol-1 and further supports the potential therapeutic actions of this neutral endopeptidase inhibitor[2].

[1]. Bevan EG, et al. Candoxatril, a neutral endopeptidase inhibitor: efficacy and tolerability in essential hypertension. J Hypertens. 1992 Jul;10(7):607-13. [2]. M Aleksinskaya, et al. Neutral endopeptidase inhibitors SOL-1 and candoxatril counteract kidney fibrosis by reducing myofibroblast formation in mouse UUO model. Bmc Pharmacology & Toxicology , 2013 , 14 (1) :1-2.

实验参考方法

Animal experiment:

Mice[2]Mice (n=10 per group) subjected to UUO are treated for 1 week with either Solvent, SOL-1 (NEP-/ECE-inhibitor two doses), Candoxatril (reference NEP inhibitor) or losartan (angiotensin AT1-receptor antagonist) and compared to sham operated animals[2].

References:

[1]. Bevan EG, et al. Candoxatril, a neutral endopeptidase inhibitor: efficacy and tolerability in essential hypertension. J Hypertens. 1992 Jul;10(7):607-13.
[2]. M Aleksinskaya, et al. Neutral endopeptidase inhibitors SOL-1 and candoxatril counteract kidney fibrosis by reducing myofibroblast formation in mouse UUO model. Bmc Pharmacology & Toxicology , 2013 , 14 (1) :1-2.

化学性质

Cas No. 123122-55-4 SDF
别名 坎沙曲,UK 79300
Canonical SMILES O=C(C1(CCCC1)C[C@@H](COCCOC)C(OC2=CC=C(CCC3)C3=C2)=O)N[C@H]4CC[C@@H](C(O)=O)CC4
分子式 C29H41NO7 分子量 515.64
溶解度 Soluble in DMSO 储存条件 Store at -20°C
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.9393 mL 9.6967 mL 19.3934 mL
5 mM 0.3879 mL 1.9393 mL 3.8787 mL
10 mM 0.1939 mL 0.9697 mL 1.9393 mL
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