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Carbazomycin A Sale

目录号 : GC48878

A bacterial metabolite with diverse biological activities

Carbazomycin A Chemical Structure

Cas No.:75139-39-8

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1mg
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5mg
¥7,521.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Carbazomycin A is a bacterial metabolite that has been found in Streptomyces and has diverse biological activities.1,2 It is active against S. aureus, T. asteroides, and T. mentagrophytes (MIC = 12.5 µg/ml for all), as well as the plant pathogenic fungus P. oryzae (MIC = 25 µg/ml). Carbazomycin A is cytotoxic to MCF-7, KB, NCI H187, and Vero cells (IC50s = 26.2, 30.1, 18.4, and 32.6 µg/ml, respectively).2

1.Sakano, K.-I., Ishimaru, K., and Nakamura, S.New antibiotics, carbazomycins A and B. I. Fermentation, extraction, purification and physico-chemical and biological propertiesJ Antibiot. (Tokyo)33(7)683-689(1980) 2.Intaraudom, C., Rachtawee, P., Suvannakad, R., et al.Antimalarial and antituberculosis substances from Streptomyces sp. BCC26924Tetrahedron67(39)7593-7597(2011)

Chemical Properties

Cas No. 75139-39-8 SDF
Canonical SMILES COC(C(C)=C(C)C1=C2C3=C(C=CC=C3)N1)=C2OC
分子式 C16H17NO2 分子量 255.3
溶解度 储存条件 -20°C
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1 mg 5 mg 10 mg
1 mM 3.917 mL 19.5848 mL 39.1696 mL
5 mM 0.7834 mL 3.917 mL 7.8339 mL
10 mM 0.3917 mL 1.9585 mL 3.917 mL
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Research Update

A General Carbazole Synthesis via Stitching of Indole-Ynones with Nitromethanes: Application to Total Synthesis of Carbazomycin A, Calothrixin B, and Staurosporinone

Org Lett 2019 May 3;21(9):3372-3376.PMID:31013110DOI:10.1021/acs.orglett.9b01111.

A new, one-pot domino benzannulation reaction between indole-3-ynones and various nitromethane derivatives has been explored for a general entry to diversely functionalized carbazole frameworks (28 examples). The scope of this new benzannulation has been extended to variants like 2-chloroindole-3-ynones to eventuate in chemo-differentiated 1,2,3,4-tetrasubstituted carbazoles with retention of the nitro group. The efficacy of this strategy has been demonstrated through concise total synthesis of natural products, viz. Carbazomycin A, calothrixin B, and staurosporinone (K252c).

Deprotonative Generation and Trapping of Haloaryllithium in a Batch Reactor

Org Lett 2023 May 5;25(17):3013-3017.PMID:37083303DOI:10.1021/acs.orglett.3c00800.

A method for the regioselective functionalization of haloarenes through deprotonative lithiation is disclosed. The generated haloaryllithiums were trapped in a batch reactor with a zinc chloride diamine complex to provide organozinc species without aryne formation, which reacted with electrophiles to afford the corresponding products in 38-98% yields. This method was applied to the five-step total synthesis of Carbazomycin A on a gram scale in 33% overall yield.

Diversity oriented convergent access for collective total synthesis of bioactive multifunctional carbazole alkaloids: synthesis of Carbazomycin A, carbazomycin B, hyellazole, chlorohyellazole, and clausenaline D

Org Lett 2014 Oct 17;16(20):5470-3.PMID:25296703DOI:10.1021/ol502721r.

Facile syntheses of imperative carbazole alkaloids Carbazomycin A, carbazomycin B, hyellazole, chlorohyellazole, and clausenaline D have been demonstrated starting from readily available Boc-protected 3-formylindole and dimethyl maleate. The suitably substituted aromatic rings have been designed comprising three/four significant C-C bond forming reactions. The competent Wittig reaction, selective monoalkylations, one-pot regioselective Weinreb amide formation and Boc-deprotection, well designed Grignard reactions, dehydrative intramolecular cyclizations, and Baeyer-Villiger rearrangement of aromatic aldehydes were the main features.

New antibiotics, carbazomycins A and B. I. Fermentation, extraction, purification and physico-chemical and biological properties

J Antibiot (Tokyo) 1980 Jul;33(7):683-9.PMID:7410212DOI:10.7164/antibiotics.33.683.

An unidentified Streptomyces, designated as Strain H 1051-MY 10, was proved to produce viomycin and two new antibiotics. The new antibiotics were extracted from the cultured mycelia with acetone and transferred to ethyl acetate after acetone was removed in vacuo. The extracted antibiotics were separated into two components by alumina column chromatography and named carbazomycins A and B, because both antibiotics were proved to contain a carbazole nucleus. The molecular formulae of carbazomycins A and B were determined to be C16H17NO2 and C15H15NO2, respectively. Further, carbazomycin B was methylated with diazomethane to give Carbazomycin A. Carbazomycins inhibited the growth of phytophathogenic fungi and further showed weak antibacterial and antiyeast activities.