Carbazomycin C
目录号 : GC48850
A bacterial metabolite with diverse biological activities
Cas No.:108073-62-7
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Carbazomycin C is a bacterial metabolite that has been found in Streptomyces and has diverse biological activities.1,2,3 It is active against S. aureus, B. anthracis, B. subtilis, and M. flavus (MICs = 50, 25, 100, and 50 µg/ml, respectively), the fungi T. asteroides and T. mentagrophytes (MICs = 25 and 100 µg/ml, respectively), and P. falciparum (IC50 = 2.1 µg/ml).2 It is also active against a panel of five plant pathogenic fungi (MICs = 12.5-100 µg/ml).1 Carbazomycin C is cytotoxic to MCF-7, KB, and NCI H187 cells (IC50s = 9.8, 21.4, and 8.2 µg/ml, respectively).2 It also inhibits 5-lipoxygenase (5-LO) activity in RBL-1 cell extracts (IC50 = 1.9 µM).3
1.Naid, T., Kitahara, T., Kaneda, M., et al.Carbazomycins C, D, E and F, minor components of the carbazomycin complexJ. Antibiot. (Tokyo)40(2)157-164(1987) 2.Intaraudom, C., Rachtawee, P., Suvannakad, R., et al.Antimalarial and antituberculosis substances from Streptomyces sp. BCC26924Tetrahedron67(39)7593-7597(2011) 3.Hook, D.J., Yacobucci, J.J., O'Connor, S., et al.Identification of the inhibitory activity of carbazomycins B and C against 5-lipoxygenase, a new activity for these compoundsJ. Antibiot. (Tokyo)43(10)1347-1348(1990)
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 3.686 mL | 18.4298 mL | 36.8596 mL |
| 5 mM | 0.7372 mL | 3.686 mL | 7.3719 mL |
| 10 mM | 0.3686 mL | 1.843 mL | 3.686 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。