Carbutamide
(Synonyms: 氨磺丁脲,BZ-55) 目录号 : GC39547
A first generation sulfonylurea
Cas No.:339-43-5
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Carbutamide is a first generation sulfonylurea.1 It inhibits ATP-sensitive potassium (KATP) channels in β-cells with an IC50 value of 173 ?M.2 It reduces blood glucose levels in anesthetized dogs when administered at a dose of 50 mg/kg.3 Carbutamide also increases ventricular fibrillation in a rat model of cardiac ischemia induced by left anterior descending (LAD) coronary artery ligation.1 Formulations containing carbutamide have previously been used in the treatment of diabetes.
1.Ballagi-Pordány, G., K?szeghy, A., Koltai, M.Z., et al.Divergent cardiac effects of the first and second generation hypoglycemic sulfonylurea compoundsDiabetes Res. Clin. Pract.8(2)109-114(1990) 2.Schwanstecher, C., Meyer, M., Schwanstecher, M., et al.Interaction of N-benzoyl-D-phenylalanine and related compounds with the sulphonylurea receptor of β-cellsBr. J. Pharmacol.123(6)1023-1030(1998) 3.Pozza, G., Galansino, G., and Foà, P.P.Insulin secretion following carbutamide injections in normal dogsProc. Soc. Exp. Biol. Med.93(3)539-542(1956)
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 3.6854 mL | 18.4271 mL | 36.8541 mL |
| 5 mM | 0.7371 mL | 3.6854 mL | 7.3708 mL |
| 10 mM | 0.3685 mL | 1.8427 mL | 3.6854 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。