Carvacrol methyl ether
(Synonyms: 香芹酚甲醚) 目录号 : GC61640
Carvacrolmethylether,一种香芹酚的类似物，是植物挥发油的成分。Carvacrolmethylether具有抗菌活性。
Cas No.:6379-73-3
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Carvacrol methyl ether, a Carvacrol analog, can be isolated from plant volatile oil. Carvacrol methyl ether exhibits antibacterial activity[1][2].
[1]. Dorman HJ, et, al. Antimicrobial agents from plants: antibacterial activity of plant volatile oils. J Appl Microbiol. 2000 Feb;88(2):308-16. [2]. Ultee A, et, al. The phenolic hydroxyl group of carvacrol is essential for action against the food-borne pathogen Bacillus cereus. Appl Environ Microbiol. 2002 Apr;68(4):1561-8.
| Cas No. | 6379-73-3 | SDF | |
| 别名 | 香芹酚甲醚 | ||
| Canonical SMILES | CC(C1=CC=C(C)C(OC)=C1)C | ||
| 分子式 | C11H16O | 分子量 | 164.24 |
| 溶解度 | DMSO : ≥ 100 mg/mL (608.87 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 6.0887 mL | 30.4433 mL | 60.8865 mL |
| 5 mM | 1.2177 mL | 6.0887 mL | 12.1773 mL |
| 10 mM | 0.6089 mL | 3.0443 mL | 6.0887 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
The anti-dermatophyte activity of Zataria multiflora essential oils
J Mycol Med 2017 Jun;27(2):232-237.PMID:28347599DOI:10.1016/j.mycmed.2017.03.001.
Objective: Dermtophytes are a group of pathogenic fungi and the major cause of dermatophytosis in humans and animals. Fighting dermatophytes by natural essential oils is one important issue in new researches. Materials and methods: In this investigation, we evaluated the anti-dermatophyte activities of three samples of Z. multiflora essential oils against dermatophytes along with analysis of chemical compositions of the essential oils and their anti-elastase activities on elastase production in dermatophytes. Results: Carvacrol (1.5-34.4%), thymol (25.8-41.2%), Carvacrol methyl ether (1.9-28.3%) and p-cymene (2.3-8.3%) were the main components of Z. multiflora essential oils. Z. multiflora essential oils (100ppm) inhibited the mycelium growth of dermatophytes (6±1.7-47.0±1.4%) and had the minimal inhibitory concentration (MIC) and minimal fungicidal concentration (MFC) values of 0.03-0.25μl/ml against dermatophytes. Essential oils inhibited elastase produced in dermatophytes and pure porcine elastase. Conclusion: Z. multiflora essential oils can be used as natural anti-dermatophyte agent for fighting dermatophytes in further preclinical and clinical studies.
Essential Oil from Origanum dictamnus
Planta Med 1987 Feb;53(1):107-9.PMID:17268981DOI:10.1055/s-2006-962640.
The essential oil of ORIGANUM DICTAMNUS L. was obtained by steam distillation with a yield of 0.8% of dry material. The oil was investigated after fractionation on a silica gel column and separation of phenols, by combination of GLC-mass spectrometry. In the analysis, 30 components were found accounting for 98.28% of the oil, the predominating compounds being carvacrol; gamma-terpinene, P-cymene, caryophyllene, borneol, terpin-1-en-4-ol, and Carvacrol methyl ether.
Antimicrobial activity of carvacrol related to its chemical structure
Lett Appl Microbiol 2006 Aug;43(2):149-54.PMID:16869897DOI:10.1111/j.1472-765X.2006.01938.x.
Aims: To investigate the relation between the chemical structure and the antimicrobial activity of carvacrol, eugenol, menthol and two synthesized carvacrol derivative compounds: Carvacrol methyl ether and carvacryl acetate against bacteria, Escherichia coli, Pseudomonas fluorescens, Staphylococcus aureus, Lactobacillus plantarum, Bacillus subtilis, a yeast Saccharomyces cerevisiae and one fungi Botrytis cinerea. Methods and results: The antimicrobial activity was tested in liquid and vapour phases, by both broth liquid and microatmosphere methods, respectively. The same classification of the compound's antimicrobial efficiency was found with both methods. Eugenol and menthol exhibited a weaker antimicrobial activity than carvacrol, the most hydrophobic compound. Carvacryl acetate and Carvacrol methyl ether were not efficient, indicating that the presence of a free hydroxyl group is essential for antimicrobial activity. Conclusions: The different extents of antimicrobial aroma compounds' efficiency showed that hydrophobicity is an important factor and the presence of a free hydroxyl group and a delocalized system allows proton exchange. Significance and impact of the study: This study has identified the importance of the hydrophobicity and the chemical structure of phenolic aroma compounds for antimicrobial activity and may contribute to a most rational use of these compounds as antimicrobial agent.
Essential oil diversity of European Origanum vulgare L. (Lamiaceae)
Phytochemistry 2015 Nov;119:32-40.PMID:26454793DOI:10.1016/j.phytochem.2015.09.008.
This investigation focused on the qualitative and quantitative composition of essential oil compounds of European Origanum vulgare. Extracts of 502 individual O. vulgare plants from 17 countries and 51 populations were analyzed via GC. Extracts of 49 plants of 5 populations of Israeli Origanum syriacum and 30 plants from 3 populations of Turkish Origanum onites were included to exemplify essential oil characteristics of 'high-quality' oregano. The content of essential oil compounds of European O. vulgare ranged between 0.03% and 4.6%. The monoterpenes were primarily made up of sabinene, myrcene, p-cymene, 1,8-cineole, β-ocimene, γ-terpinene, sabinene hydrate, linalool, α-terpineol, Carvacrol methyl ether, linalyl acetate, thymol and carvacrol. Among the sesquiterpenes β-caryophyllene, germacrene D, germacrene D-4-ol, spathulenol, caryophyllene oxide and oplopanone were often present in higher amounts. According to the proportions of cymyl-compounds, sabinyl-compounds and the acyclic linalool/linalyl acetate three different main monoterpene chemotypes were defined. The cymyl- and the acyclic pathway were usually active in plants from the Mediterranean climate whereas an active sabinyl-pathway was a characteristic of plants from the Continental climate.
Variations in Essential Oil Compositions of Lavandula pubescens (Lamiaceae) Aerial Parts Growing Wild in Yemen
Chem Biodivers 2017 Mar;14(3).PMID:27701813DOI:10.1002/cbdv.201600286.
Lavandula pubescens Decne. is one of five Lavandula species growing wild in Yemen. The plant is used in Yemeni traditional medicine, and the essential oil tends to be rich in carvacrol. In this work, L. pubescens was collected from eight different locations in Yemen, the essential oils obtained by hydrodistillation, and the oils analyzed by gas chromatography/mass spectrometry (GC/MS). Principal component analysis (PCA) and hierarchical cluster analysis (HCA) were used to differentiate between the L. pubescens samples. The essential oils were rich in carvacrol (60.9 - 77.5%), with lesser concentrations of Carvacrol methyl ether (4.0 - 11.4%), caryophyllene oxide (2.1 - 6.9%), and terpinolene (0.6 - 9.2%). The essential oil compositions in this study showed very high similarity, but it was possible to discern two separate groups based on minor components, in particular the concentrations of terpinolene, Carvacrol methyl ether, m-cymen-8-ol, and caryophyllene oxide.