Carvedilol metabolite 4-Hydroxyphenyl Carvedilol
(Synonyms: 卡维地洛对羟基代谢物,4-Hydroxyphenyl Carvedilol; 4-Hydroxycarvedilol) 目录号 : GC33579An active metabolite of carvedilol
Cas No.:142227-49-4
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
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- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
4’-hydroxyphenyl Carvedilol is a metabolite of carvedilol that is a more potent β-adrenergic receptor antagonist than carvedilol but has weaker vasodilatory activity.1 It is formed through oxidation primarily by the cytochrome P450 (CYP) isoform CYP2D6.2 4’-hydroxyphenyl Carvedilol inhibits the formation of DPPH radicals in a cell-free assay.3
1.Patel, D.P., Sharma, P., Sanyal, M., et al.UPLC-MS/MS assay for the simultaneous quantification of carvedilol and its active metabolite 4'-hydroxyphenyl carvedilol in human plasma to support a bioequivalence study in healthy volunteersBiomed. Chromatogr.27(8)974-986(2013) 2.Oldham, H.G., and Clarke, S.E.In vitro identification of the human cytochrome P450 enzymes involved in the metabolism of R(+)- and S(–)-carvedilolDrug Metab. Dispos.25(8)970-977(1997) 3.Malig, T.C., Ashkin, M.R., Burman, A.L., et al.Comparison of free-radical inhibiting antioxidant properties of carvedilol and its phenolic metabolitesMedchemcomm.8(3)606-615(2017)
Cas No. | 142227-49-4 | SDF | |
别名 | 卡维地洛对羟基代谢物,4-Hydroxyphenyl Carvedilol; 4-Hydroxycarvedilol | ||
Canonical SMILES | OC1=CC=C(OCCNCC(O)COC2=CC=CC(N3)=C2C4=C3C=CC=C4)C(OC)=C1 | ||
分子式 | C24H26N2O5 | 分子量 | 422.47 |
溶解度 | Acetonitrile: slightly soluble,Methanol: slightly soluble | 储存条件 | Store at -20°C |
General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。 为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。 |
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Shipping Condition | 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。 |
制备储备液 | |||
1 mg | 5 mg | 10 mg | |
1 mM | 2.367 mL | 11.8352 mL | 23.6703 mL |
5 mM | 0.4734 mL | 2.367 mL | 4.7341 mL |
10 mM | 0.2367 mL | 1.1835 mL | 2.367 mL |
第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量) | ||||||||||
给药剂量 | mg/kg | 动物平均体重 | g | 每只动物给药体积 | ul | 动物数量 | 只 | |||
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方) | ||||||||||
% DMSO % % Tween 80 % saline | ||||||||||
计算重置 |
计算结果:
工作液浓度: mg/ml;
DMSO母液配制方法: mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL,
体内配方配制方法:取 μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL saline,混匀澄清。
1. 首先保证母液是澄清的;
2.
一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。