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Carvedilol metabolite 4-Hydroxyphenyl Carvedilol Sale

(Synonyms: 卡维地洛对羟基代谢物,4-Hydroxyphenyl Carvedilol; 4-Hydroxycarvedilol) 目录号 : GC33579

An active metabolite of carvedilol

Carvedilol metabolite 4-Hydroxyphenyl Carvedilol Chemical Structure

Cas No.:142227-49-4

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2mg
¥1,428.00
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5mg
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10mg
¥4,016.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

4’-hydroxyphenyl Carvedilol is a metabolite of carvedilol that is a more potent β-adrenergic receptor antagonist than carvedilol but has weaker vasodilatory activity.1 It is formed through oxidation primarily by the cytochrome P450 (CYP) isoform CYP2D6.2 4’-hydroxyphenyl Carvedilol inhibits the formation of DPPH radicals in a cell-free assay.3

1.Patel, D.P., Sharma, P., Sanyal, M., et al.UPLC-MS/MS assay for the simultaneous quantification of carvedilol and its active metabolite 4'-hydroxyphenyl carvedilol in human plasma to support a bioequivalence study in healthy volunteersBiomed. Chromatogr.27(8)974-986(2013) 2.Oldham, H.G., and Clarke, S.E.In vitro identification of the human cytochrome P450 enzymes involved in the metabolism of R(+)- and S(–)-carvedilolDrug Metab. Dispos.25(8)970-977(1997) 3.Malig, T.C., Ashkin, M.R., Burman, A.L., et al.Comparison of free-radical inhibiting antioxidant properties of carvedilol and its phenolic metabolitesMedchemcomm.8(3)606-615(2017)

Chemical Properties

Cas No. 142227-49-4 SDF
别名 卡维地洛对羟基代谢物,4-Hydroxyphenyl Carvedilol; 4-Hydroxycarvedilol
Canonical SMILES OC1=CC=C(OCCNCC(O)COC2=CC=CC(N3)=C2C4=C3C=CC=C4)C(OC)=C1
分子式 C24H26N2O5 分子量 422.47
溶解度 Acetonitrile: slightly soluble,Methanol: slightly soluble 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.367 mL 11.8352 mL 23.6703 mL
5 mM 0.4734 mL 2.367 mL 4.7341 mL
10 mM 0.2367 mL 1.1835 mL 2.367 mL
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