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Caspofungin-d4 (acetate) Sale

目录号 : GC45892

A neuropeptide with diverse biological activities

Caspofungin-d4 (acetate) Chemical Structure

规格 价格 库存 购买数量
500μg
¥3,854.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Caspofungin-d4 (acetate) is intended for use as an internal standard for the quantification of caspofungin by GC- or LC-MS. Caspofungin is an antifungal compound that is classified as an echinocandin, as it acts by noncompetititvely inhibiting the enzyme 1,3-β glucan synthase and preventing the synthesis of glucan in the fungal cell wall.1 It is effective against disseminated or invasive aspergillosis and candidiasis.2,3 Caspofungin has a 50% minimum effective concentration against Aspergillus spp. of 0.015 μg/ml.4 It does not antagonize other antifungal compounds, like amphotericin B, and, in some cases, may show additive or synergistic activity.1,3,5

|1. Letscher-Bru, V., and Herbrecht, R. Caspofungin: The first representative of a new antifungal class. J. Antimicrob. Chemother. 51(3), 513-521 (2003).|2. Abruzzo, G.K., Flattery, A.M., Gill, C.J., et al. Evaluation of the echinocandin antifungal MK-0991 (L-743,872): Efficacies in mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis. Antimicrob. Agents Chemother. 41(11), 2333-2338 (1997).|3. Deresinski, S.C., and Stevens, D.A. Caspofungin. Clin. Infect. Dis. 36(11), 1445-1457 (2003).|4. Pfaller, M.A., Boyken, L., Hollis, R.J., et al. In vitro susceptibility of clinical isolates of Aspergillus spp. to anidulafungin, caspofungin, and micafungin: A head-to-head comparison using the CLSI M38-A2 broth microdilution method. J. Clin. Microbiol. 47(10), 3323-3325 (2009).|5. Herbrecht, R., Nivoix, Y., Fohrer, C., et al. Management of systemic fungal infections: Alternatives to itraconazole. J. Antimicrob. Chemother. 56(Suppl 1), i39-i48 (2005).

Chemical Properties

Cas No. N/A SDF
分子式 C52H84D4N10O15.2C2H4O2 分子量 1217.5
溶解度 Methanol: slightly soluble,Water: slightly, heated 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 0.8214 mL 4.1068 mL 8.2136 mL
5 mM 0.1643 mL 0.8214 mL 1.6427 mL
10 mM 0.0821 mL 0.4107 mL 0.8214 mL
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动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
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% DMSO % % Tween 80 % saline
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