Search results for: 'Peptide'

Cat.No. 产品名称 Information

GC40554 Ac-Calpastatin (184-210)

Calpastatin Peptide B27-WT

A specific inhibitor of calpains I and II

GC33759 GLP-1(7-36) Acetate (Human GLP-1-(7-36)-amide Acetate)

Glucagon-like peptide-1 (GLP-1)(7-36), amide acetate; Human GLP-1 (7-36), amide acetate

GLP-1(7-36) Acetate (Human GLP-1-(7-36)-amide Acetate) 是一种主要的肠道激素，可从 β 刺激葡萄糖诱导的胰岛素分泌；细胞。

GC14472 VIP (human, rat, mouse, rabbit, canine, porcine)

阿肽地尔; Vasoactive Intestinal Peptide (human, rat, mouse, rabbit, canine, porcine)

VIP（人、大鼠、小鼠、兔、犬、猪）是一种类似的血管活性肠多肽 (VIP)，具有有效的血管舒张作用。

GC17040 DAPTA

D-Ala-peptide T-amide; Adaptavir

A CCR5 receptor antagonist

GC12217 VIP (guinea pig)

Vasoactive Intestinal Peptide, guinea pig

VIP 豚鼠（血管活性肠肽）是一种营养和有丝分裂因子，可刺激整个培养胚胎的生长。

GC13461 ZIP (SCRAMBLED)

加扰控制肽,z-Pseudosubstrate inhibitory peptide

ZIP (SCRAMBLED) 是 zeta 抑制肽 (ZIP) 的乱序对照肽。

GC17514 SLIGRL-NH2

Protease-Activated Receptor-2 Activating Peptide

A PAR2 agonist

GC17193 MOG (35-55)

髓鞘少突胶质细胞糖蛋白,endrocyte Glycoprotein Peptide (35-55)

MOG (35-55)是髓磷脂少突胶质细胞糖蛋白的35-55片段。

GA21423 ent-[Amyloid β-Protein (20-16)]-β-Ala-D-Lys(ent-[Amyloid β-Protein (16-20)]) This all-D peptide contains two retro-inverso peptide klvff motifs of KLVFF (H-3682) corresponding to amino acids 16 to 20 of amyloid β-protein. The tandem dimer retro-inverso peptide showed about a 100-fold higher binding affinity (Kd = 1.3 . 10?² µM) for amyloid β-protein (1-40) fibrils than KLVFF (Kd = 1.1 ± 0.3 µM). It was also found to be more effective in preventing ordered fibril formation than the parent peptide KLVFF as judged by its increased ability to inhibit thioflavin T binding to β-sheet structures.

GA20182 (Gln²²)-Amyloid β-Protein (1-40) The Dutch mutation (E22Q) of amyloid β-peptide aggregates more readily than the wild-type peptide and the resulting fibrils show increased neurotoxicity. The mutant peptide E22Q induced apoptosis of cerebral endothelial cells at a concentration of 25 μm, whereas WT Aβ 1-40 and the Italian mutant E22K (H-6698) showed no effect.

GC16243 β-Amyloid (1-42), human TFA

大豆肽

淀粉样蛋白 β 肽 (1-42) 人 TFA 是一种由 42 个氨基酸组成的肽。

GC91862 Exendin-3 (9-39) amide (trifluoroacetate salt)

Exendin (9-39)

Exendin-3 (9-39) amide is a truncated form of the exendin-4 (48-86) amide peptide that acts as a potent competitive antagonist for the glucagon-like peptide 1 receptor (GLP-1R; Kd = 1.7 nM in CHL cells transfected with cloned human GLP-1).

GA20739 Amyloid β-Protein (1-6) amide Experiments using sub-peptides of Aβ42 revealed that the epitope identified by the antibody A8, as described by Ying and coworkers, lies within the 1-6 region of Aβ. The antibody displays high affinity for soluble Aβ42 oligomers in the molecular weight range of 16.5-25 kDa, and detected target antigen in brain sections from senescence-accelerated SAMP 8 mice. Amidated or acetylated and amidated forms of the sequence were used for example for quantitative structure retention relationships (QSRR) experiments. The latter could allow prediction of reversed-phase high-performance liquid chromatography (HPLC) retention of peptides, as reported by Kaliszan and coworkers.

GA20727 Amyloid β-Protein (1-39) Small quantities of Aβ37, 38 and 39 can be detected in CSF together with Aβ40, the most abundant Aβ homolog, Aβ42, and N-terminally truncated amyloid peptides. The relative amounts depend on the variant of Alzheimer's disease. The C-terminally truncated amyloid peptides are also found in amyloid plaques.

GA20720 Amyloid β-Protein (10-35) Amyloid β-protein (10-35), YEVHHQKLVFFAEDVGSNKGAIIGLM, was used as a truncated peptide model for the full-length amyloid β-proteins (1-40) and (1-42) in high-resolution structural studies. In contrast to the full-length amyloid β-proteins, amyloid β-protein (10-35) allowed the controlled and reproducible formation of homogeneous fibrils from aqueous solutions of defined pH, ionic strength and soluble peptide concentration necessary for high-resolution structural studies.

GA20535 Acetyl-Amyloid β-Protein (1-6) amide Experiments using sub-peptides of Aβ42 revealed that the epitope identified by the antibody A8, as described by Ying and coworkers, lies within the 1-6 region of Aβ. The antibody displays high affinity for soluble Aβ42 oligomers in the molecular weight range of 16.5-25 kDa, and detected target antigen in brain sections from senescence-accelerated SAMP 8 mice. Amidated or acetylated and amidated forms of the sequence were used for example for quantitative structure retention relationships (QSRR) experiments. The latter could allow prediction of reversed-phase high-performance liquid chromatography (HPLC) retention of peptides, as reported by Kaliszan and coworkers.

GA20533 Acetyl-Amyloid β/A4 Protein Precursor₇₇₀ (96-110) (cyclized)

乙酰基-淀粉样肽Β/A4蛋白质前体770(APP)(96-110)(环化)

This cyclized peptide which is homologous to the heparin-binding domain of APP, binds strongly to heparin and inhibits binding of ¹²?I-labeled APP to heparin (IC??= 10??M). The peptide blocks the heparan sulfate proteoglycan-dependent stimulatory effect of APP on neurite outgrowth.

GA20284 (Pyr³)-Amyloid β-Protein (3-42)

(PYR3)-淀粉Β-蛋白

(Pyr³)-Amyloid β-Protein (3-42) was found to be the predominant amyloid β-peptide structure deposited in human brain of Alzheimer's disease and Down's syndrome patients. Therefore, (Pyr³)-Aβ (3-42) is suggested to accumulate in the brain and to trigger the formation of insoluble amyloid β-peptide deposits. Nussbaum et al. studies the Prion-like behaviour and tau-dependent cytotoxicity of the truncated Aβ sequence.

GA20030 (Arg⁶)-Amyloid β-Protein (1-40) The English (H6R) mutation of β-amyloid peptides accelerates fibrillation without increasing protofibril formation. Ono et al. showed that the English and Tottori mutations alter Abeta assembly at its earliest stages, monomer folding and oligomerization, and produce oligomers that are more toxic to cultured neuronal cells than are wild type oligomers. The exchange of His? by Arg influences the structure of the Cu(II) complex formed by Aβ peptides.

GA20024 (7-Diethylaminocoumarin-3-yl)carbonyl-Amyloid β-Protein (1-40) Amyloid β-protein (1-40) that is N-terminally modified with the fluorescent dye (7-diethylaminocoumarin-3-yl)carbonyl (DAC or DEAC). This derivative can be utilized to assess the binding properties of amyloid β-protein (1-40) for various membranes since it behaves very similar to the native peptide. In aqueous environments the fluorophore is almost non-fluorescent whereas binding to membranes results in an increase in fluorescence intensity (Λex = 430 nm, Λem = 470 nm). Increases in the GM1 ganglioside and cholesterol content in the lipid bilayers facilitated the binding of this peptide. For phosphatidylcholine and phosphatidylserine no affinity was observed.

GC43644 Exendin-4 (acetate)

醋酸艾塞那肽; Exenatide acetate

A GLP-1R agonist

GC91871 Tirzepatide (sodium salt)

LY3298176

Tirzepatide is an agonist of glucagon-like peptide 1 receptor (GLP-1R) and gastric inhibitory polypeptide (GIP) receptor.

GC91869 Retatrutide (sodium salt)

LY3437943

Retatrutide is a triple agonist of the glucagon receptor (GCGR), glucagon-like peptide 1 receptor (GLP-1R), and gastric inhibitory polypeptide receptor (GIP receptor), also known as the glucose-dependent insulinotropic polypeptide receptor.

GC91867 SNX-482 (ammonium salt) SNX-482 is a peptide originally isolated from H. gigas venom that acts as a class E/R-type voltage-sensitive calcium channel blocker (IC50 = 30 nM in 192C cells expressing human class E channels).

GC91866 Apelin-36 (trifluoroacetate salt) The apelin gene encodes a preproprotein that is processed to generate a variety of bioactive peptides, including those having 36, 17, or 13 amino acids (apelin-36, apelin-17, and apelin-13, respectively).

GC91865 WaTx (36-68) (scorpion) (trifluoroacetate salt)

Wasabi Receptor Toxin (36-68)

Wasabi receptor toxin (WaTx) (36-68) is a cell-penetrating peptide that corresponds to the mature toxin sequence and is an activator of transient receptor potential ankyrin 1 (TRPA1).

GC91859 LL-37 (13-37) (human) (trifluoroacetate salt)

CAP-18,hCAP-18,Cathelicidin,FALL-39,IG-25,LL-13,LL-25

LL-37 (13-37) is an anticancer peptide fragment of LL-37 .

GC91858 [Ala1,3,11,15]-Endothelin-1 (trifluoroacetate salt)

4-Ala-ET-1,Ala1,3,11,15-ET-1

[Ala1,3,11,15]-Endothelin-1 is an endothelin receptor type B (ETB) agonist and linear synthetic peptide derivative of endothelin-1 in which all four cysteine residues have been substituted with alanine.

GC91855 M40 (trifluoroacetate salt)

Galanin-(1-12)-Pro3-(Ala-Leu)2-Ala amide

M40 is a chimeric galanin-derived peptide and galanin-1 (GAL1) receptor antagonist and GAL2 receptor agonist (Kis = 2.4 and 4.07 nM, respectively).

GC91850 MDM2 (32-46) (trifluoroacetate salt) MDM2 (32-46) is a peptide fragment of MDM2.

GC91848 CH 275 (acetate) CH 275 is a cyclic peptide agonist of somatostatin receptor 1 (SST1; IC50 = 30.9 nM for the human receptor).

GC91846 Mastoparan 7 (trifluoroacetate salt)

Mas7

Mastoparan 7 is a G protein activator and derivative of the mast cell degranulating peptide mastoparan.

GC91840 HBP08 (trifluoroacetate salt) HBP08 is a peptide inhibitor of the protein-protein interaction between chemokine (C-X-C motif) ligand 12 (CXCL12) and high mobility group protein B1 (HMGB1).

GC91836 [Asp371]-Tyrosinase (369-377) (human) (trifluoroacetate salt)

Asp370-Tyrosinase (368-376),Tyr-Met-Asp-Gly-Thr-Met-Ser-Gln-Val

[Asp371]-Tyrosinase (369-377) is a naturally occurring tyrosinase antigen peptide.

GC91826 HCKFWW (trifluoroacetate salt)

His-Cys-Lys-Phe-Trp-Trp-OH,HW6

HCKFWW is a thiol-containing peptide and form of the HIV-1 integrase inhibitor HCKFWW-NH2.

GC91825 Bradykinin (2-9) (trifluoroacetate salt)

BK (2-9),(Des-Arg1)-BK,(Des-Arg1)-Bradykinin,H-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH

Bradykinin (2-9) is a metabolite of the endogenous vasodilator peptide bradykinin.

GC91810 PE 22-28 (acetate)

Gly-Val-Ser-Trp-Gly-Leu-Arg-OH

PE 22-28 is a peptide inhibitor of the two-pore domain potassium channel K2P2.1/TREK1 (IC50 = 0.1 nM in HEK293 cells expressing the human channel) and a fragment of spadin .

GC91788 Acetyl Tetrapeptide-3 (acetate) Acetyl tetrapeptide-3 is a biomimetic peptide.

GC91627 Semaglutide (sodium salt) Semaglutide is an agonist of glucagon-like peptide 1 receptor (GLP-1R; EC50 = 6.2 pM in a reporter assay using BHK cells expressing the human receptor).

GC91626 N-formyl-Nle-Leu-Phe-Nle-Tyr-Lys (trifluoroacetate salt)

fNLFNYK

N-formyl-Nle-Leu-Phe-Nle-Tyr-Lys (fNLFNYK) is a synthetic chemotactic peptide.

GC91538 Fexapotide (trifluoroacetate)

NX-1207

Fexapotide (trifluoroacetate) is a peptide.

GC90628 Transportan (trifluoroacetate salt)

一种细胞穿透肽（Cell-penetrating peptide）

GC90535 Penetratin (trifluoroacetate salt)

Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-NH2

一种细胞穿透肽（Cell-penetrating peptide）

GA24160 Rink amide AM resin (200-400 mesh, 0.5-1.2 mmol/g)

Knorr resin

Fmoc-Rink amide-AM resin, a standard resin for the Fmoc-SPPS of peptide amides.

GA24159 RAD16-I

PuraMatrix

Self-assembling amphiphilic peptide used as scaffold in tissue engineering and 3-dimensional cell culture.

GA24158 Protein LMWP

Low Molecular Weight Protamine

Low molecular weight protamine (LMWP) is a peptide fragment produced in our laboratory from enzymatic digestion of native protamine.

GA24156 Prion Protein (106-126) (human) (scrambled) The 21-peptide NGAKALMGGHGATKVMVGAAA, a scrambled sequence of the human prion protein (106-126), is an important control in the study of the biological activity of prion protein peptides.

GA24145 LL-37 (scrambled)

Cationic Antimicrobial Protein 18 (134-170) (Scrambled) (human)

Control peptide for LL37.

GA24131 H-Lys-Phe-Glu-Arg-Gln-OH The peptide plays a widespread role in targeting proteins for enhanced degradation.

GA24129 H-Leu-Gly-Leu-Leu-Leu-Arg-His-Leu-Arg-His-His-Ser-Asn-Leu-Leu-Ala-Asn-Ile-OH The peptide sequence B18, derived from the membrane-associated sea urchin sperm protein bindin, triggers fusion between lipid vesicles.

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