CCM2 Human
目录号 : GP22980Cerebral Cavernous Malformation 2 Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greaterthan 90.0% as determined by SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile Filtered clear solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | Cerebral Cavernous Malformation 2; C7orf22; malcavernin; CerebralCavernous Malformations 2 Protein; Chromosome 7 Open Reading Frame 22; OSM; MGC4067. | ||
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSEVKYLGQ LTSIPGYLNP SSRTEILHFI DNAKRAHQLP GHLTQEHDAVLSLSAYNVKL AWRDGEDIIL RVPIHDIAAV SYVRDDAAHL VVLKTDDSST KVDIKETYEV EASTFCFPESVDVGGASPHS KTISESELSA SATELLQDYM LTLRTKLSSQ EIQQFAALLH EYRNGASIHE FCINLRQLYG DSRKFLLLGL RPFIPEKDSQHFENFLETIG VKDGRGIITD SFGRHRRALS TTSSSTTNGN RATGSSDDRS APSEGDEWDR MISDISSDIEALGCSMDQDS A | ||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles. | ||
| Formulation | CCM2 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 20% glycerol and1mM DTT. | ||
CerebralCavernous Malformation 2, also known as CCM2 is a piece of the CCM signalingpathway which is a vital regulator of heart and vessel formation as well asintegrity. CCM2 performs through the stabilization of endothelial celljunctions. In addition, CCM2 functions as a scaffold protein for MAP2K3-MAP3K3signaling. CCM2 plays a key role in the modulation of MAP3K3-dependent p38activation induced by hyperosmotic shock. Mutations in CCM2 result in cerebralcavernous malformations. Multiple transcript variants encoding dissimilarisoforms have been discoveredfor CCM2.
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.