CD33 Human
目录号 : GP23048CD33 Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greaterthan 90% as determined by SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile Filtered clear solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | CD33Molecule; CD33Antigen (Gp67); Sialic AcidBinding Ig-Like Lectin 3; Sialic Acid-Binding Ig-Like Lectin 3; SIGLEC3; gp67; SIGLEC-3;Myeloid Cell Surface AntigenCD33; p67; Siglec-3; CD33Antigen. | ||
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSDPNFWLQ VQESVTVQEG LCVLVPCTFF HPIPYYDKNS PVHGYWFREG AIISGDSPVA TNKLDQEVQE ETQGRFRLLG DPSRNNCSLS IVDARRRDNG SYFFRMERGS TKYSYKSPQL SVHVTDLTHR PKILIPGTLE PGHSKNLTCS VSWACEQGTP PIFSWLSAAP TSLGPRTTHS SVLIITPRPQ DHGTNLTCQV KFAGAGVTTE RTIQLNVTYV PQNPTTGIFP GDGSGKQETR AGVVH. | ||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles. | ||
| Formulation | CD33 protein solution (1mg/ml) containing 20mM Tris-HClbuffer (pH 8.0), 0.4M Urea, and 10% glycerol. | ||
CD33is putative adhesion molecule of myelomonocytic-derived cells which mediatessialic-acid dependent binding to cells. CD33 prefers to bind toalpha-2,6-linked sialic acid. The sialic acid recognition site is masked by cisinteractions with sialic acids on the same cell surface. In the immuneresponse, CD33 perform as an inhibitory receptor upon ligand induced tyrosinephosphorylation by recruiting cytoplasmic phosphatases through their SH2domains which block signal transduction through dephosphorylation of signalingmolecules. In addition, CD33 induces apoptosis in acutemyeloid leukemia.
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.