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Cdk2/Cyclin Inhibitory Peptide I Sale

(Synonyms: H2N-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Pro-Val-Lys-Arg-Arg-Leu-Phe-Gly-OH ) 目录号 : GP10098

Cell division protein kinase 2

Cdk2/Cyclin Inhibitory Peptide I Chemical Structure

Cas No.:237392-84-6

规格 价格 库存 购买数量
1mg
¥315.00
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5mg
¥830.00
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10mg
¥1,481.00
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25mg
¥1,995.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Cyclin-dependent kinase 2 also known as cell division protein kinase 2[1]. The protein encoded by this gene is a member of the cyclin-dependent kinase family of Ser/Thr protein kinases. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, also known as Cdk1 in humans. It is a catalytic subunit of the cyclin-dependent kinase complex, whose activity is restricted to the G1-S phase of the cell cycle, and is essential for the G1/S transition. This protein associates with and is regulated by the regulatory subunits of the complex including cyclin E or A. Cyclin E binds G1 phase Cdk2, which is required for the transition from G1 to S phase while binding with Cyclin A is required to progress through the S phase. Its activity is also regulated by phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported[2]. The role of this protein in G1-S transition has been recently questioned as cells lacking Cdk2 are reported to have no problem during this transition[3].

References:
1. Lawrie, A. M.; Noble, M. E.; Tunnah, P.; Brown, N. R.; Johnson, L. N.; Endicott, J. A. (1997). "Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2". Nature structural biology 4 (10): 796–801
2. Tsai LH, HarlowE, Meyerson M (September 1991). "Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase". Nature 353 (6340): 174–7.
3. Berthet C, Aleem E, Coppola V, Tessarollo L, Kaldis P (October 2003). "Cdk2 knockout mice are viable". Curr. Biol. 13 (20): 1775–85.

Chemical Properties

Cas No. 237392-84-6 SDF
别名 H2N-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Pro-Val-Lys-Arg-Arg-Leu-Phe-Gly-OH
分子式 C111H196N48O23 分子量 2571.05
溶解度 ≥ 257.1mg/mL in DMSO 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 0.3889 mL 1.9447 mL 3.8895 mL
5 mM 0.0778 mL 0.3889 mL 0.7779 mL
10 mM 0.0389 mL 0.1945 mL 0.3889 mL
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