Cecropin A (trifluoroacetate salt)

Cecropin A is an antimicrobial peptide that has been found in H. cecropia.^1,2 It induces apoptosis in C. albicans when used at a concentration of 5 µM.² Cecropin A is active against the planktonic and uropathogenic E. coli strain CFT073 (MIC = 100 µg/ml) and increases survival of CFT073-infected G. mellonella larvae.¹ Cecropin A (15 mg/kg) decreases enrichment of the gut microflora Bacteroidaceae and Enterobacteriaceae and increases gut levels of Lactobacillus, as well as increases survival and decreases body weight loss in a mouse model of inflammatory bowel disease (IBD) induced by dextran sulfate .³

1.Kalsy, M., Tonk, M., Hardt, M., et al.The insect antimicrobial peptide cecropin A disrupts uropathogenic Escherichia coli biofilmsNPJ Biofilms Microbiomes6(1)6(2020) 2.Yun, J., and Lee, D.G.Cecropin A-induced apoptosis is regulated by ion balance and glutathione antioxidant system in Candida albicansIUBMB Life68(8)652-662(2016) 3.Zhai, Z., Zhang, F., Cao, R., et al.Cecropin A alleviates inflammation through modulating the gut microbiota of C57BL/6 mice with DSS-induced IBDFront. Microbiol.101595(2019)