Cefamandole (sodium salt)
(Synonyms: 头孢孟多酯钠; Cephamandole sodium) 目录号 : GC16920
A cephalosporin antibiotic
Cas No.:30034-03-8
Sample solution is provided at 25 µL, 10mM.
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MIC: 0.25-2 mg/L for different E. coli strains
Cefamandole is a cephalosporin antibiotic.
The cephalosporins are a class of β-lactam antibiotics originally derived from the fungus Acremonium, which was previously known as "Cephalosporium".
In vitro: The in-vitro effect of cefamandole was tested against 645 strains of bacteria isolated from clinical sources. Against gram-positive organisms cefamandole showed great potency, being three- to four-fold more active than cephalexin or cefoxitin. None of the Pseudomonas aeruginosa strains were susceptible to 100 μg of cefamandole per ml [1].
In vivo: The testicular toxicity of cefamandole was evaluated in neonatal rats. Results showed that cefamandole caused delayed maturity of the germinal epithelium of neonatal rats. In rats given daily subcutaneous injections during this period, the most mature germinal cells were acrosome phase spermatids [2].
Clinical trial: A randomized, single-blind comparison of parenteral cefamandole and ampicillin was conducted in adult patients with pneumonia or purulent tracheobronchitis. Results showed that cefamandole was as effective and safe as ampicillin. Of the 14 patients treated with cefamandole, 13 were considered cured, as were 12 of the 13 treated with ampicillin [3].
References:
[1] Eickhoff TC, Ehret JM. In vitro comparison of cefoxitin, cefamandole, cephalexin, and cephalothin. Antimicrob Agents Chemother. 1976 Jun;9(6):994-9.
[2] Hoover DM, Buening MK, Tamura RN, Steinberger E. Effects of cefamandole on spermatogenic development of young CD rats. Fundam Appl Toxicol. 1989 Nov;13(4):737-46.
[3] Delgado DG, Brau CJ, Cobbs CG, Dismukes WE. Clinical and laboratory evaluation of cefamandole in the therapy of Haemophilus spp. Bronchopulmonary infections. Antimicrob Agents Chemother. 1979 Jun;15(6):807-12.
| Cas No. | 30034-03-8 | SDF | |
| 别名 | 头孢孟多酯钠; Cephamandole sodium | ||
| 化学名 | (6R,7R)-7-[[(2R)-2-hydroxy-2-phenylacetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, monosodium salt | ||
| Canonical SMILES | O=C(N[C@@H]1C(N2[C@]1([H])SCC(CSC3=NN=NN3C)=C2C([O-])=O)=O)[C@H](O)C4=CC=CC=C4.[Na+] | ||
| 分子式 | C18H17N6O5S2 • Na | 分子量 | 484.5 |
| 溶解度 | ≤30mg/ml in DMSO;30mg/ml in dimethyl formamide | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.064 mL | 10.3199 mL | 20.6398 mL |
| 5 mM | 0.4128 mL | 2.064 mL | 4.128 mL |
| 10 mM | 0.2064 mL | 1.032 mL | 2.064 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet