Cefonicid (sodium salt)
(Synonyms: 头孢尼西钠) 目录号 : GC17813
A cephalosporin antibiotic
Cas No.:61270-78-8
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Cefonicid is a second-generation cephalosporin antibiotic.
Cephalosporins, the largest and most diverse family of antibiotics of the beta-lactam group, are structurally and pharmacologically related to the penicillins.
In vitro: Cefonicid was found to be similar to cefamandole in its superiority to first generation cephalosporins against several enterobacteriaceae and Haemophilus influenzae, such as beta-lactamase-producing strains. Its activity against Staphylococcus aureus was similar to that of cefoxitin and inferior to cefamandole and first generation cephalosporins. Cefonicid has excellent in-vitro activity against Neisseria gonorrhoeae, but is inactive against Pseudomonas, Serratia, Acinetobacter, and Bacteroides fragilis [1].
In vivo: The purpose of a previous study was to determine whether cefonicid caused testicular toxicity when subcutaneously administered to Sprague-Dawley male rats at doses of 50 to 1,000 mg/kg per day. The histological findings were confirmed by marked reductions in testicular sperm production rates and cauda epididymal sperm numbers. In addition, cefonicid had no treatment-related adverse effects on the sexual maturation males [2].
Clinical trial: Cefonicid was found to be comparable in efficacy with cefamandole or cefazolin in the treatment of patients with urinary tract, lower respiratory tract, and soft tissue and bone infections. It was also compared with penicillin in the treatment of uncomplicated gonorrhoea. Single doses of cefonicid appear to offer a similar degree of protection against post-surgical infection as multiple doses of other antibiotics [1].
References:
[1] Saltiel, E; Brogden, R. N. (1986). Cefonicid. A review of its antibacterial activity, pharmacological properties and therapeutic use. Drugs. 32 (3): 222–59.
[2] Manson JM, Zolna LE, Kang YJ, Johnson CM. Effects of cefonicid and other cephalosporin antibiotics on male sexual development in rats. Antimicrob Agents Chemother. 1987 Jul;31(7):991-7.
| Cas No. | 61270-78-8 | SDF | |
| 别名 | 头孢尼西钠 | ||
| 化学名 | (6R,7R)-7-[[(2R)-2-hydroxy-2-phenylacetyl]amino]-8-oxo-3-[[[1-(sulfomethyl)-1H-tetrazol-5-yl]thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, disodium salt | ||
| Canonical SMILES | O=C(N[C@H]1[C@](SCC(CSC2=NN=NN2CS([O-])(=O)=O)=C3C([O-])=O)([H])N3C1=O)[C@H](O)C4=CC=CC=C4.[Na+].[Na+] | ||
| 分子式 | C18H16N6O8S3 • 2Na | 分子量 | 586.5 |
| 溶解度 | ≥ 22.95mg/mL in DMSO | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
||
| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 1.705 mL | 8.5251 mL | 17.0503 mL |
| 5 mM | 0.341 mL | 1.705 mL | 3.4101 mL |
| 10 mM | 0.1705 mL | 0.8525 mL | 1.705 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。