Cefuroxime sodium (Cefuroxime sodium salt)

Cefuroxime is a cephalosporin antibiotic with broad-spectrum activity against Gram-positive and Gram-negative bacteria including S. pyogenes, S. pneumoniae, S. viridans, E. coli, P. mirabilis, H. influenzae, and N. gonorrhoeae (mean MICs = 0.005-8.2 μg/ml).¹ Like other cephalosporins, cefuroxime inhibits peptidoglycan crosslinking and bacterial cell wall synthesis.² It is resistant to hydrolysis by bacterial β-lactamases, increasing its efficacy against β-lactamase producing Gram-negative bacteria.³ Cefuroxime is protective against Gram-positive and Gram-negative infections in vivo with mean ED₅₀ values ranging from 2 to 35 and 1 to 55 mg/kg, in mice and rats, respectively.⁴ Formulations containing cefuroxime have been used to treat urinary tract infections.⁵

1.O'Callaghan, C.H., Sykes, R.B., Griffiths, A., et al.Cefuroxime, a new cephalosporin antibiotic: Activity in vitroAntimicrob. Agents Chemother.9(3)511-519(1976) 2.Curtis, N.A.C., Hughes, J.M., and Ross, G.W.Inhibition of peptidoglycan cross-linking in growing cells of Escherichia coli by penicillins and cephalosporins, and its prevention by R factor-mediated beta-lactamaseAntimicrob. Agents Chemother.9(2)208-213(1976) 3.Richmond, M.H., and Wotton, S.Comparative study of seven cephalosporins: Susceptibility to beta-lactamases and ability to penetrate the surface layers of Escherichia coliAntimicrob. Agents Chemother.10(2)219-222(1976) 4.Ryan, D.M., O'Callaghan, C.H., and Muggleton, P.W.Cefuroxime, a new cephalosporin antibiotic: Activity in vivoAntimicrob. Agents Chemother.9(3)520-525(1976) 5.Masika, W.G., O'Meara, W.P., Holland, T.L., et al.Contribution of urinary tract infection to the burden of febrile illnesses in young children in rural KenyaPLoS One12(3)e0174199(2017)