Ceritinib-d7
(Synonyms: 色瑞替你-D7,LDK378 D7) 目录号 : GC45789
An internal standard for the quantification of ceritinib
Cas No.:1632484-77-5
Sample solution is provided at 25 µL, 10mM.
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Ceritinib-d7 is intended for use as an internal standard for the quantification of ceritinib by GC- or LC-MS. Ceritinib is an inhibitor of anaplastic lymphoma kinase (ALK) with an IC50 value of 200 pM in an enzyme assay.1,2 It less potently inhibits IGF-1R, InsR, and STK22D (IC50s = 8, 7, and 23 nM, respectively) and is minimally effective against a panel of other kinases. Ceritinib inhibits ALK in cells (IC50 = 25 nM) and in vivo, producing tumor regression in a rat xenograft model.1 It is also effective against several crizotinib-resistant mutants of ALK.3
|1. Awad, M.M., and Shaw, A.T. ALK inhibitors in non-small cell lung cancer: Crizotinib and beyond. Clin. Adv. Hematol. Oncol. 12(7), 429-439 (2014).|2. Sullivan, I., and Planchard, D. ALK inhibitors in non-small cell lung cancer: The latest evidence and developments. Ther. Adv. Med. Oncol. 8(1), 32-47 (2016).|3. Fontana, D., Ceccon, M., Gambacorti-Passerini, C., et al. Activity of second-generation ALK inhibitors against crizotinib-resistant mutants in an NPM-ALK model compared to EML4-ALK. Cancer Med. 4(7), 953-965 (2016).
| Cas No. | 1632484-77-5 | SDF | |
| 别名 | 色瑞替你-D7,LDK378 D7 | ||
| Canonical SMILES | CC(C=C(NC1=NC=C(Cl)C(NC2=CC=CC=C2S(C(C)C)(=O)=O)=N1)C(OC(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])=C3)=C3C4CCNCC4 | ||
| 分子式 | C28H29D7ClN5O3S | 分子量 | 565.2 |
| 溶解度 | DMSO : ≥ 12.5 mg/mL (22.12 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 1.7693 mL | 8.8464 mL | 17.6929 mL |
| 5 mM | 0.3539 mL | 1.7693 mL | 3.5386 mL |
| 10 mM | 0.1769 mL | 0.8846 mL | 1.7693 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet