Cetaben
(Synonyms: 西他苯) 目录号 : GC16301
A non-fibrate hypolipidemic drug
Cas No.:55986-43-1
Sample solution is provided at 25 µL, 10mM.
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Cetaben is an unique PPARα-independent peroxisome proliferator.
The fibrate class of hypolipidemic drugs, such as fenofibrate and clofibrate, elicit their effects via binding to and activating peroxisome proliferator-activated receptor α (PPARα).
In vitro: Previous study showed that cetaben could cause little but reversible proliferation and morphological heterogeneity with the occurrence of dumbbell- and cup-shaped peroxisomal profiles. Peroxisomes in HepG2 cells showed marked variation in size and shape. Cetaben treatment of HepG2 cells was able to lead to disintegration of Golgi regions and augmented mitochondrial matrix [1].
In vivo: Animal study found that the changes in large scale of liver non-peroxisomal parameters were compared after 10 days administration of both cetaben and clofibric acid 200 mg/kg/day to male Wistar rats. No analogical changes were observed after cetaben treatment in the livers of experimental animals. It was also found that both drugs could increase the activities of alanine-glyoxylate aminotransferase-1 and acetylcarnitine transferase--enzymes with proven mitochondrial and peroxisomal location. Contrary to clofibric acid, cetaben did not increase solubilization of peroxisomal enzymes [2].
Clinical trial: So far, no clinical study has been conducted.
References:
[1] Kovacs, W. ,Walter, I., and Stangl, H. Cetaben-induced changes on the morphology and peroxisomal enzymes in MH1C1 rat hepatoma and HepG2 human hepatoblastoma cells. Histochemistry and Cell Biology 115, 509-519 (2001).
[2] Chandoga, J. ,Hampl, L.,Turecky, L., et al. Cetaben is an exceptional type of peroxisome proliferator. International Journal of Biochemistry 26(5), 679-696 (1994).
| Cas No. | 55986-43-1 | SDF | |
| 别名 | 西他苯 | ||
| 化学名 | 4-(hexadecylamino)-benzoic acid | ||
| Canonical SMILES | CCCCCCCCCCCCCCCCNC1=CC=C(C(O)=O)C=C1 | ||
| 分子式 | C23H39NO2 | 分子量 | 361.6 |
| 溶解度 | ≤1mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 2.7655 mL | 13.8274 mL | 27.6549 mL |
| 5 mM | 0.5531 mL | 2.7655 mL | 5.531 mL |
| 10 mM | 0.2765 mL | 1.3827 mL | 2.7655 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet