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CGP 65015 Sale

目录号 : GC30589

CGP65015是一种可口服的铁螯合剂,可以清除铁沉积。

CGP 65015 Chemical Structure

Cas No.:189564-33-8

规格 价格 库存 购买数量
1mg
¥10,059.00
现货
5mg
¥16,092.00
现货
10mg
¥25,748.00
现货

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Sample solution is provided at 25 µL, 10mM.

Description

CGP 65015 is an oral iron chelator, which can mobilize iron deposits.

CGP 65015 is an oral iron chelator[1].

CGP65015 (150 μmol IBE/kg p.o. on d0) dramatically increases the urinary and faecal iron clearance, and still enhances iron elimination during the second post-treatment day in iron-overloaded marmosets[1].

[1]. Sergejew T, et al. Chelator-induced iron excretion in iron-overloaded marmosets. Br J Haematol. 2000 Sep;110(4):985-92.

实验参考方法

Animal experiment:

Marmosets[1]To approximate the iron status of thalassaemic patients in the marmosets, the animals are iron-overloaded by three i.p. injections of iron (III) hydroxide polyisomaltose at 14-d intervals (200 mg/kg twice and 100 mg/kg at the third injection). Prior to the first exposure to an iron chelator (CGP 65015), the marmosets are rested for at least 8 weeks in order to allow definite distribution of the injected iron into all storage compartments. CGP 65015 is dispersed in 40% aqueous Cremophor RH 40 for oral administration of 150 μmol IBE/kg. All dosages are expressed in terms of 'iron binding equivalents' (IBE) which take into account the stoichiometry of the chelator in the iron complex, i.e. 150 μmol IBE correspond to 150, 300 and 450 μmol of a mono-, bi- and tridentate chelator respectively. The standard dose is 150 μmol iron binding equivalents (IBE) per kg body weight. The applied volume is 5 mL/kg body weight[1].

References:

[1]. Sergejew T, et al. Chelator-induced iron excretion in iron-overloaded marmosets. Br J Haematol. 2000 Sep;110(4):985-92.

化学性质

Cas No. 189564-33-8 SDF
Canonical SMILES O=C1C(O)=C(C(O)C2=CC=CC=C2)N(CCO)C=C1
分子式 C14H15NO4 分子量 261.27
溶解度 Soluble in DMSO 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

制备储备液
1 mg 5 mg 10 mg
1 mM 3.8275 mL 19.1373 mL 38.2746 mL
5 mM 0.7655 mL 3.8275 mL 7.6549 mL
10 mM 0.3827 mL 1.9137 mL 3.8275 mL
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第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
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