CH 275 (acetate)
目录号 : GC91848CH 275 is a cyclic peptide agonist of somatostatin receptor 1 (SST1; IC50 = 30.9 nM for the human receptor).
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
CH 275 is a cyclic peptide agonist of somatostatin receptor 1 (SST1; IC50 = 30.9 nM for the human receptor).[1] It is selective for SST1 over SST2, SST3, SST4, and SST5 (IC50s = >10,000, 345, >1,000, and >10,000 nM, respectively, for the human receptors). CH 275 (500 nM) inhibits basal growth hormone secretion from primary mouse pituitary cells.[2] It inhibits glucose-induced increases in electrical activity without inducing membrane hyperpolarization in a whole-cell patch-clamp assay using MIN6 pancreatic β-cells when used at a concentration of 100 nM.[3]
References:
[1].Rivier, J.E., Hoeger, C., Erchegyi, J., et al.Potent somatostatin undecapeptide agonists selective for somatostatin receptor 1 (sst1)J. Med. Chem.44(13)2238-2246(2001).
[2].Kreienkamp, H.J., Akgün, E., Baumeister, H., et al.Somatostatin receptor subtype 1 modulates basal inhibition of growth hormone release in somatotrophsFEBS Lett.462(3)464-466(1999).
[3].Smith, P.A., Sellers, L.A., and Humphrey, P.P.Somatostatin activates two types of inwardly rectifying K+ channels in MIN-6 cellsJ. Physiol.532(Pt 1)127-142(2001).
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 0.673 mL | 3.3652 mL | 6.7304 mL |
| 5 mM | 0.1346 mL | 0.673 mL | 1.3461 mL |
| 10 mM | 0.0673 mL | 0.3365 mL | 0.673 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。