Chloramphenicol succinate sodium
(Synonyms: 氯霉素琥珀酸钠) 目录号 : GC39661
A prodrug form of chloramphenicol
Cas No.:982-57-0
Sample solution is provided at 25 µL, 10mM.
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Chloramphenicol succinate is a water-soluble prodrug form of the antibiotic chloramphenicol.1 It is a substrate for succinate dehydrogenase (SDH) and is oxidized by human liver and rat liver and kidney mitochondria to release chloramphenicol in vitro.2 Chloramphenicol succinate reduces human leukocyte migration in vitro.3 In vivo, chloramphenicol succinate reduces E. coli growth in rabbit and rat models of pyelonephritis when administered at doses of 150 and 200 mg/kg, respectively.4 Chloramphenicol succinate (20 mg/kg) reduces infarct size in a porcine model of myocardial ischemia-reperfusion injury.5 Formulations containing chloramphenicol succinate have been used in the treatment of severe bacterial infections.
1.Ceriotti, G., Defranceschi, A., De Carneri, I., et al.Chloramphenicol succinate, a water-soluble derivative of chloramphenicolFarmaco Sci.9(1)21-38(1954) 2.Ambekar, C.S., Lee, J.S., Cheung, B.M., et al.Chloramphenicol succinate, a competitive substrate and inhibitor of succinate dehydrogenase: Possible reason for its toxicityToxicol. In Vitro18(4)441-447(2004) 3.Forsgren, A., and Schmeling, D.Effect of antibiotics of chemotaxis of human leukocytesAntimicrob. Agents Chemother.11(4)590-584(1977) 4.Prat, V., Konickova, L., Ritzerfeld, W., et al.Effect of chloramphenicol against different E. coli strains in vitro and in experimental pyelonephritisArzneimittelforschung18(9)1123-1127(1968) 5.Sala-Mercado, J.A., Wider, J., Undyala, V.V., et al.Profound cardioprotection with chloramphenicol succinate in the swine model of myocardial ischemia-reperfusion injuryCirculation122(11 Suppl)S179-S184(2010)
| Cas No. | 982-57-0 | SDF | |
| 别名 | 氯霉素琥珀酸钠 | ||
| Canonical SMILES | O=C(OC[C@@H](NC(C(Cl)Cl)=O)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1)CCC([O-])=O.[Na+] | ||
| 分子式 | C15H15Cl2N2NaO8 | 分子量 | 445.18 |
| 溶解度 | DMSO: 250 mg/mL (561.57 mM) | 储存条件 | -20°C, protect from light, stored under argon |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.2463 mL | 11.2314 mL | 22.4628 mL |
| 5 mM | 0.4493 mL | 2.2463 mL | 4.4926 mL |
| 10 mM | 0.2246 mL | 1.1231 mL | 2.2463 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet