Chlorantraniliprole

Chlorantraniliprole is an anthranilic diamide insecticide and agonist of ryanodine receptors located on the sarcoplasmic reticulum in muscle and endoplasmic reticulum in non-muscle cells.¹ It binds to a different site than ryanodine on the receptor and stimulates the release of calcium from intracellular stores with EC₅₀ values ranging from 40 to 50 nM for P. americana neurons and H. virescens or D. melanogaster recombinant ryanodine receptors. It is highly selective for insect over mammalian ryanodine receptors (EC₅₀s = 14,000 nM, >100 ?M, and >100 ?M for C2C12 mouse, PC12 rat, and IMR32 human cells, respectively).² Chlorantraniliprole is active against insects of the order Lepidoptera, including larvae of the fall armyworm (S. frugiperda), diamondback moth (P. xylostella), and tobacco budworm (H. virescens) with EC₅₀ values of 0.02, 0.01, and 0.05 ppm, respectively, and of the orders Coleoptera, Diptera, and Isoptera. Formulations containing chlorantraniliprole have been used in agriculture to control moths, beetles, and caterpillars among other insects.

1.Lahm, G.P., Cordova, D., and Barry, J.D.New and selective ryanodine receptor activators for insect controlBioorg. Med. Chem.17(12)4127-4133(2009) 2.Lahm, G.P., Stevenson, T.M., Selby, T.P., et al.Rynaxypyr?: A new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activatorBioorg. Med. Chem. Lett.17(22)6274-6279(2007)