Chlorotoxin (trifluoroacetate salt)

Name: Chlorotoxin (trifluoroacetate salt)
SKU: GC92127
Availability: InStock
Rating: 5 (30 reviews)

(Synonyms: CTX; TM-601) 目录号 : GC92127

Chlorotoxin (trifluoroacetate salt)是从蝎L. quinquestriatus的毒液中分离出来的肽。

Chlorotoxin (trifluoroacetate salt) Chemical Structure

规格价格库存购买数量

500 µg	¥5,586.00	现货
1 mg	¥8,932.00	现货

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Sample solution is provided at 25 µL, 10mM.

GlpBio产品文献引用

Nature
610.7931 (2022): 366-372

Nature
618, 1017–1023 (2023)

Cell
183.7 (2020): 1867-1883

Cell Research
31, 1291–1307 (2021)

Cell Research
33, 273–287 (2023)

Cell Research
33, 546–561 (2023)

Molecular Cancer
21.1 (2022): 1-17

Molecular Cancer
21.1 (2022): 1-18

Cancer Cell
39 (2021): 1-16

Cell Host Microbe
30.8 (2022): 1124-1138

Cell Host Microbe
31.5 (2023): 766-780

Cell Host Microbe
31.3 (2023): 418-43

Cell Metabolism
34.2 (2022): 240-255

Ann Rheum Dis
82(4): 533-545 (2023)

Cell Mol Immunol
20, 264–276 (2023)

Adv Funct Mater
33.35 (2023): 2214998

产品描述化学性质产品文档

Description

Chlorotoxin is a peptide originally isolated from the venom of the scorpion L. quinquestriatus.^1,2 It inhibits chloride currents in rat colonic enterocyte plasma membrane preparations when used at a concentration of 594 nM.¹ Chlorotoxin also binds to, but does not inhibit, matrix metalloproteinase-2 (MMP-2; IC₅₀s = 0.71 and >30 ?M, respectively), as well as neuropilin-1 (NRP-1; IC₅₀ = 0.78 ?M) in cell-free assays.³ It induces paralysis in crayfish (P. clarkii) but is not cytotoxic to human U87MG glioma, MCF-7 breast cancer, PC3 prostate cancer, and A549 lung cancer cells.^1,2 Administration of chimeric antigen receptor (CAR) T cells expressing CAR with chlorotoxin as the targeting domain increase survival and decrease tumor volume in an orthotopic patient-derived xenograft (PDX) mouse model of glioblastoma.⁴ Liposomes containing chlorotoxin and encapsulating doxorubicin decrease tumor volume in a U87 glioma mouse xenograft model.⁵ Fluorescently labeled chlorotoxin has been used for tumor imaging in vivo.⁶

References:
[1]. DeBin, J.A., Maggio, J.E., and Strichartz, G.R.Purification and characterization of chlorotoxin, a chloride channel ligand from the venom of the scorpionAm. J. Physiol.264(2 Pt 1)C361-C369(1993).
[2]. Ayed, A.S., Omran, M.A.A.A., Nabil, Z.I., et al.C-terminal amidation of chlorotoxin does not affect tumour cell proliferation and has no effect on toxin cytotoxicityInt. J. Pept. Res. Ther.27(1)659-667(2021).
[3]. Farkas, S., Cioca, D., Murányi, J., et al.Chlorotoxin binds to both matrix metalloproteinase 2 and neuropilin 1J. Biol. Chem.299(9)104998(2023).
[4]. Wang, D., Starr, R., Chang, W.C., et al.Chlorotoxin-directed CAR T cells for specific and effective targeting of glioblastomaSci. Transl. Med.12(533)eaaw2672(2020).
[5]. Xiang, Y., Liang, L., Wang, X., et al.Chloride channel-mediated brain glioma targeting of chlorotoxin-modified doxorubicine-loaded liposomesJ. Control Release152(3)402-410(2011).
[6]. Veiseh, M., Gabikian, P., Bahrami, S.B., et al.Tumor paint: A chlorotoxin:Cy.
[5]. 5 bioconjugate for intraoperative visualization of cancer fociCancer Res.67(14)6882-6888(2007).

化学性质

Cas No.		SDF
别名	CTX; TM-601
化学名	L-methionyl-L-cysteinyl-L-methionyl-L-prolyl-L-cysteinyl-L-phenylalanyl-L-threonyl-L-threonyl-L-α-aspartyl-L-histidyl-L-glutaminyl-L-methionyl-L-alanyl-L-arginyl-L-lysyl-L-cysteinyl-L-α-aspartyl-L-α-aspartyl-L-cysteinyl-L-cysteinylglycylglycyl-L-lysylglycyl-L-arginylglycyl-L-lysyl-L-cysteinyl-L-tyrosylglycyl-L-prolyl-L-glutaminyl-L-cysteinyl-L-leucyl-L-cysteinyl-L-argininamide, cyclic (2→19),(5→28),(16→33),(20→35)-tetrakis(disulfide), trifluoroacetate salt
Canonical SMILES	OC(C[C@H](NC([C@]([H])([C@@H](C)O)NC([C@]([H])([C@@H](C)O)NC([C@@H](NC([C@H]1NC([C@@H]2CCCN2C([C@H](CCSC)NC([C@H]3NC([C@H](CCSC)N[H])=O)=O)=O)=O)=O)CC4=CC=CC=C4)=O)=O)=O)C(N[C@@H](CC5=CNC=N5)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCSC)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN[H])C(N[C@@H]6C(N[C@@H](CC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CSSC3)C(N[C@@H]7C(NCC(NCC(N[C@@H](CCCCN[H])C(NCC(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CCCCN[H])C(N[C@@H](CSSC1)C(N[C@@H](CC(C=C8)=CC=C8O)C(NCC(N9CCC[C@H]9C(N[C@@H](CCC(N)=O)C(N[C@@H](CSSC6)C(N[C@H](C(N[C@@H](CSSC7)C(N[C@@H](CCCNC(N)=N)C(N)=O)=O)=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
分子式	C₁₅₈H₂₄₉N₅₃O₄₇S₁₁ ? XCF₃COOH	分子量	3995.7
溶解度	Water: Sparingly soluble: 1-10 mg/ml	储存条件	-20°C
General tips	请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。
Shipping Condition	评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。

溶解性数据

制备储备液
		1 mg	5 mg	10 mg
	1 mM	0.2503 mL	1.2513 mL	2.5027 mL
	5 mM	0.0501 mL	0.2503 mL	0.5005 mL
	10 mM	0.025 mL	0.1251 mL	0.2503 mL

摩尔浓度计算器
稀释计算器
分子量计算器

计算

动物体内配方计算器 (澄清溶液)

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方）

% DMSO+ % + % Tween 80+ % saline

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系GLPBIO）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。

产品文档

Quality Control & SDS

View current batch:

Purity: >95.00%